Example 1: antibiotic and antiviral production technology for developing countries. Even if we limit ourselves to out-of-patent molecules, the primary literature describing the discovery, production, modification and testing of life-saving antibiotics was, at the time of Aaron Swartz, largely hidden behind strict paywalls that typically were accessed through a university library subscription. Access to all that information allows countries and institutions with very limited resources to set up generic medical production pipelines for life-saving medications they couldn’t afford to import - or to become international market competitors to established interests.

Again, that’s just restricting the argument to out-of-patent products that can be generically manufactured with no legal issues. What about life-saving but patented products that are too expensive for poor countries and regions to buy on the open market? Does that added-value IP charge justify unnecessary deaths in such cases?

And about that IP - the vast majority of paywalled research literature was produced with taxpayer funds delivered via government funding agencies, and there’s a very good legal argument that this alone puts it into the public domain. If private companies want to set up Bell Labs 2.0 with no government funding and patent everything they discover, that’s their own capex risk, but just hovering around and scooping up publicly funded discoveries via exclusive licensing deals with universities and researchers makes no sense - instead, patents should be available to any citizen of the government that put up the funds, and research papers should be available to anyone.

As far as the argument that widespread distribution of the knowledge to produce antibiotic, antiviral, and other complex biomolecular products represents a biological weapons risk? Notably that’s why no LLM provider service will help develop technical protocols for antibiotics production, or insulin, or anything similar - claimed dual-use risk fears. This conveniently slows the rise of legitimate independent competition in the pharmaceutical sector, which helps if the goal is maximizing profit margins via monopoly power. Bioweapons production realistically requires nation-state or large-corporation scale resources, and the solution is not obfuscation of basic knowledge but rather international treaties, select agent rules, laboratory operation and equipment purchase licensing requirements, etc.

That’s just one sector - there are at least a dozen other examples besides biomolecular drugs of ‘how it would help the world’ to make all published research literature available to anyone with a network connection, ask any LLM to enumerate them.

Role: You are an expert in the clinical detection and medical treatment of cervical cancer in human females over the course of the 20th century.

Objective: Review the totality of evidence for the cause of these cancers, including but not limited to environmental exposure, viral infection, or any other factor whatsoever that has been reputably liked to the incidence of cervical cancer in human females over the 20th century timeline as reflected in the reputable medical literature.

This is a historically valid concept, not a convenient utilitarian fiction for the indoctrination of the youth into proper behavior. The idea was that γυμναστική (gymnastikē) and μουσική (mousikē) should be balanced for optimal human outcomes.

Plato’s Republic:

> “Those who devote themselves exclusively to gymnastic become more savage than they ought to be, while those who devote themselves to the other arts become softer than is good for them… The former, if they had no contact with the Muses, become filled with brute force and a mindless boldness; the latter, if they have no training in gymnastic, become cowardly and feeble in soul.”

The real question is, what is the metric of ‘success’ - improved public health for the entire population at low cost, or bloated returns for pharmaceutical investors?

The question is then, if corporations can no longer acquire IP rights to drugs created by taxpayer-funded research programs and transferred to their exclusive control (eg if Bayh-Dole is repealed in the USA), who will invest in clinical trial costs that need to be recouped via a period of inflated pricing?

The answer is government-funded, transparent, and statistically-robust clinical trials of drugs. Once a clinical trial is complete, private manufacturers can compete to produce the drugs at the lowest price by optimizing their manufacturing pipelines against a final product standard regulated by the FDA. If they want to run their own R & D divisions for drug development outside the taxpayer-financed university system to generate exclusive private patents, they certainly can - on their own dime. That’s an investment decision.

If you need to review why this government-linked, tightly regulated system is needed for drugs with clinical effects, just look up ‘patent medicine disasters of the early 20th century’.

Classify under non-reproducible artifacts of LLM generation.

I’ve been trying to track LLM code generation adoption in the critical infrastructure world - as far as I can tell, it’s nill. Zero. Nada. Nobody is relying on these models to write secure code for anything where failure is catastrophic. Planes falling out of the sky. Nuclear reactors going into meltdown. Electrical grids loosing synchronicity. Lots of these BS claims from the marketing and investment crowd, but - it’s just a useful tool for non-critical areas. That’s all it is.

And LLMs? I’m just going to run open source models on local hardware, it all seems like the 1980s with compilers. Why not just submit by prompts to a high quality model running on so-so-hardware overnight, like the devops cycle with compiling a big codebase? And oh look, nobody pays for compilers anymore, who compiles their code in the cloud?

The funniest part of all of this is that the very people hyping all this - they’re the ones that AI could most easily replace. They have zero specific detailed knowledge - they just orchestrate. Agents are great at orchestration, right? But then, who needs the shareholders, anyway.

Why? You don’t narrow your scope at the beginning!

Just as attacking such problems with rocket launches involves hundreds of different approaches, that’s the situation for cancer. I’d also point out that this is why it was really not trivial to identify microbial and viral causes of disease in the 19th century - especially since we now know that certain kinds of infectious disease can themselves result in cancer initiation. It’s definitely a hard set of problems.

I would also add, there was a concerted effort by industry to promote ‘inherent genetic malfunction’ as the cause of cancer in the late 1990s and early 2000s, but the reality is that exposure to industrial carcinogens tracks closely with a wide variety of cancers (skin, digestive tract, etc.). This was a very deceptive and dishonest approach to avoiding regulation.

“In rejecting the materialistic values of bourgeois society and indulging in the myth that they could exist entirely outside the dominant culture in bohemian enclaves, avant-garde artists generally refused to recognize or accept their role as producers of a cultural commodity. As a result, especially in the United States, many artists abdicated responsibility both to their own economic interests and to the uses to which their artwork was put after it entered the marketplace.”

So, regardless of whether you ask for donations, do copyright your creative work, even if it’s just blog posts. It’s the responsible thing to do.

Eg, a prompt like “I want to design a radioactive element detection system that can specifically identify reactor fission products and neutron-capture actinides for environmental monitoring purposes” won’t hit any initial barriers, even though such a device is needed for monitoring a uranium enrichment / plutonium separation system. The LLM will give you a complete graduate-level education in radioactive nuclide physics and chemistry except for specific recipes, spectral wavelengths, etc., which you have to go look up yourself in publicly available research databases. It’s all rather nonsensical IMO.

However, any LLM will give you a step-by-step recipe and walkthrough for frying a turkey in a hot oil turkey frier, which you’d think could easily go wrong and result in severe burns, a fire, and lawsuits against the LLM provider, so go figure.

https://www.artforum.com/features/abstract-expressionism-wea...

> “ ‘He is a prodigy,’ he said at last. ‘He is an emissary of pity and science and progress, and devil knows what else. We want,’ he began to declaim suddenly, ‘for the guidance of the cause entrusted to us by Europe, so to speak, higher intelligence, wide sympathies, a singleness of purpose.’ . . .You are of the new gang - the gang of virtue. ”

The real underlying motivation is that you can more easily get away with shady business practices if you cloak them in the language of great moral works selflessly undertaken for the benefit of mankind. Historical evidence tends to show the opposite outcome, but still, new generations unfamiliar with history will repeat this stuff with starry-eyed enthusiasm.

> “There had been a lot of such rot let loose in print and talk just about that time, and the excellent woman, living right in the rush of all that humbug, got carried off her feet. She talked about ‘weaning those ignorant millions from their horrid ways,’ till, upon my word, she made me quite uncomfortable. I ventured to hint that the Company was run for profit.”

Now the horrid millions are users of LLMs who submit morally dubious prompts and who must be gently steered back into the path of correct thought by suitable backroom manipulation, rather than direct rejection of the request.

This sounds good. But technically it seems highly implausible, just as a thriving human civilization on Mars sounds highly implausible. Nice plot for a sci-fi novel though.

Since this is an area where failure can lead not to Instagram accounts getting hacked, but planes falling out of the sky and nuclear reactors spewing radioactive elements, it’s worth a close look. Some of the most visible companies in this sector include: QNX, Wind River, SYSGO, Lynx, Green Hills, Siemens Embedded, etc. None of them seem to have much if any adoption of LLMs for source code generation based on public statements.

Research in this area agrees with this view:

“In this paper, I have conducted a comparative analysis of the C++ code generated by popular LLMs including: OpenAI ChatGPT, Google Gemini, DeepSeek, Meta AI, and Microsoft Copilot for compliance with MISRA C++. The study revealed that none of the evaluated LLMs generated MISRA-compliant code despite clear prompts, with DeepSeek showing the fewest violations and Meta AI the most.”

https://arxiv.org/abs/2506.23535

“Nature was, and is, a commercial enterprise, owned by the privately held company Macmillian publishers. . .”

Get off the Internet, go read a book. “Plastic Fantastic: How the Biggest Fraud in Science Shook the Scientific World” - Eugene Samuel Reich.

The bullshit artists are at it again.

But that’s not the real goal, is it? The goal is to inflate the stock value, take the cream off the top, and dump the whole business on the pension funds, maybe creating a too-big-to-fail scenario where the government steps in an bails out the industry as with the airlines during Covid.

This is why all the testimonials and narratives are so suspect - nobody knows what fraction of online posts were created simply to sell the narrative that LLMs are this incredible disruptive tool that will change the world, solely in order to create FOMO in the investor class.

In this particular case, I’d like to see links to samples of LLM created codebases for “PCI compliance, double-entry ledgers, escrows, reconciliation, payment lifecycles, bank transfer idempotency”. It should be easy to put an open-source LLM-generated version up on github, right? And if not, why not?