<rss version="2.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Hacker News: quadhome</title><link>https://news.ycombinator.com/user?id=quadhome</link><description>Hacker News RSS</description><docs>https://hnrss.org/</docs><generator>hnrss v2.1.1</generator><lastBuildDate>Mon, 15 Jun 2026 16:22:57 +0000</lastBuildDate><atom:link href="https://hnrss.org/user?id=quadhome" rel="self" type="application/rss+xml"></atom:link><item><title><![CDATA[New comment by quadhome in "Copper transport drug restores memory and clears toxic Alzheimer's proteins"]]></title><description><![CDATA[
<p><i>Alzheimer’s is driven by the buildup of toxic proteins called amyloid-beta.</i><p>In the words of Derek Lowe:<p><i>Amyloid-directed therapies truly, truly do not appear to be the answer for Alzheimer’s treatment. When I started work in the field back in the early 1990s, I was convinced of the opposite - the evidence looked very strong that defects in amyloid processing were indeed the cause of the disease. But that was thirty-five years ago, thirty-five years in which therapy after therapy after therapy aimed at amyloid mechanisms has failed.</i><p><i>[…] We’re way past persistence, way past focus, way past optimism and multiple shots on goal and old-college-tries. Do something else! For God's sake, do something else.</i><p>— <a href="https://www.science.org/content/blog-post/anti-amyloid-antibodies-alzheimer-you-already-know" rel="nofollow">https://www.science.org/content/blog-post/anti-amyloid-antib...</a></p>
]]></description><pubDate>Mon, 15 Jun 2026 15:50:07 +0000</pubDate><link>https://news.ycombinator.com/item?id=48543068</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=48543068</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48543068</guid></item><item><title><![CDATA[New comment by quadhome in "Stdx, Rust's extended standard library"]]></title><description><![CDATA[
<p>And just decided to relicense those forks with no real regard.<p>Also, it’s a loooong way from the self-contained goal—- there are a lot of third-party crates as dependencies still.<p>Yikes.</p>
]]></description><pubDate>Mon, 15 Jun 2026 15:39:31 +0000</pubDate><link>https://news.ycombinator.com/item?id=48542904</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=48542904</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48542904</guid></item><item><title><![CDATA[New comment by quadhome in "Iran Shock Jolts Asia and Europe to Speed Up Energy Transition"]]></title><description><![CDATA[
<p>You must be young. <a href="https://en.wikipedia.org/wiki/Tanker_war" rel="nofollow">https://en.wikipedia.org/wiki/Tanker_war</a></p>
]]></description><pubDate>Fri, 05 Jun 2026 12:22:39 +0000</pubDate><link>https://news.ycombinator.com/item?id=48411448</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=48411448</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48411448</guid></item><item><title><![CDATA[New comment by quadhome in "macOS needs its grid back"]]></title><description><![CDATA[
<p><a href="https://www.youtube.com/watch?v=tf03YBxCyGI" rel="nofollow">https://www.youtube.com/watch?v=tf03YBxCyGI</a></p>
]]></description><pubDate>Tue, 02 Jun 2026 10:15:28 +0000</pubDate><link>https://news.ycombinator.com/item?id=48368230</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=48368230</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48368230</guid></item><item><title><![CDATA[New comment by quadhome in "Technofascism"]]></title><description><![CDATA[
<p>Bill Gates? <a href="https://www.youtube.com/watch?v=1iPe6Iegom4" rel="nofollow">https://www.youtube.com/watch?v=1iPe6Iegom4</a></p>
]]></description><pubDate>Sun, 17 May 2026 11:24:41 +0000</pubDate><link>https://news.ycombinator.com/item?id=48167911</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=48167911</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48167911</guid></item><item><title><![CDATA[New comment by quadhome in "How OpenAI, the US government and Persona built an identity surveillance machine"]]></title><description><![CDATA[
<p>Wherein a very basic KYC system is described. Every bank and money transmitter in the US have either built an identical system or purchased one.</p>
]]></description><pubDate>Wed, 18 Feb 2026 14:18:46 +0000</pubDate><link>https://news.ycombinator.com/item?id=47061182</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=47061182</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47061182</guid></item><item><title><![CDATA[New comment by quadhome in "Dave Farber has died"]]></title><description><![CDATA[
<p>IP-Asia met every week via Zoom. Several other people whose names appear in the same literature frequented it too. Pop in tonight for the final session?</p>
]]></description><pubDate>Sun, 08 Feb 2026 14:19:56 +0000</pubDate><link>https://news.ycombinator.com/item?id=46934409</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=46934409</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=46934409</guid></item><item><title><![CDATA[New comment by quadhome in "Futurelock: A subtle risk in async Rust"]]></title><description><![CDATA[
<p><i>It's desirable to be able to express the idea that we want to continually poll drive one asynchronous operation to completion while periodically checking if some other thing has happened and taking action based on that, and then continue driving forward the ongoing operation.</i><p>This idea may be desirable; but, a deadlock is possible if there's a dependency between the two operations. The crux is the "and then continue," which I'm taking to mean that the first operation is meant to pause whilst the second operation occurs. The use of `&mut` in the code specifically enables that too.<p>If it's OK for the first operation to run concurrently with the other thing, then wrt. Tokio's APIs, have you seen LocalSet[1]? Specifically:<p><pre><code>    let local = LocalSet::new();
    local.spawn_local(async move {
        sleep(Duration::from_millis(500)).await;
        do_async_thing("op2", lock.clone()).await;
    });
    local.run_until(&mut future1).await;
</code></pre>
This code expresses your idea under a concurrent environment that resolves the deadlock. However, `op2` will still never acquire the lock because `op1` is first in the queue. I strongly suspect that isn't the intended behaviour; but, it's also what would have happened if the `select!` code had worked as imagined.<p>[1] <a href="https://docs.rs/tokio/latest/tokio/task/struct.LocalSet.html" rel="nofollow">https://docs.rs/tokio/latest/tokio/task/struct.LocalSet.html</a></p>
]]></description><pubDate>Sun, 02 Nov 2025 12:23:40 +0000</pubDate><link>https://news.ycombinator.com/item?id=45789800</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=45789800</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=45789800</guid></item><item><title><![CDATA[New comment by quadhome in "Ken Thompson recalls Unix's rowdy, lock-picking origins"]]></title><description><![CDATA[
<p>From scratch? AIUI GTA3 and Vice City were built on RenderWare.</p>
]]></description><pubDate>Mon, 27 Oct 2025 13:59:32 +0000</pubDate><link>https://news.ycombinator.com/item?id=45721106</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=45721106</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=45721106</guid></item><item><title><![CDATA[New comment by quadhome in "Epistemic Collapse at the WSJ"]]></title><description><![CDATA[
<p>> <i>But is there any major technology that post 1960s theoretical physics has given us? I can't think of any example.</i><p>Insane take. Just GPS, MRIs (high temp. supercondutors), electron microscopes, quantum computing, and chip fabs alone are relevant to us here at HN.</p>
]]></description><pubDate>Sat, 13 Sep 2025 12:44:22 +0000</pubDate><link>https://news.ycombinator.com/item?id=45231621</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=45231621</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=45231621</guid></item><item><title><![CDATA[New comment by quadhome in "Next.js is infuriating"]]></title><description><![CDATA[
<p>AsyncLocalStorage.enterWith is the wrong method; .enterWith changes the logger for across the *synchronous* execution. This doesn't matter if there's only one request happening at time-- like when you're testing locally. But that's why it didn't work on the actual project.<p>Use .run.<p><pre><code>  return LoggerStorage.run(requestLogger(), () => {
      logger()?.debug({ url: request.url }, "Started processing request!");
      return NextResponse.next();
  });</code></pre></p>
]]></description><pubDate>Tue, 02 Sep 2025 10:11:23 +0000</pubDate><link>https://news.ycombinator.com/item?id=45101055</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=45101055</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=45101055</guid></item><item><title><![CDATA[New comment by quadhome in "The Theoretical Limitations of Embedding-Based Retrieval"]]></title><description><![CDATA[
<p>Humans only retrieve information in a library in that way due to the past limitations on retrieval and processing. The invention of technologies like tables of contents or even the Dewey Decimal Classification are strongly constrained by fundamental technologies like ... the alphabet! And remember, not all languages are alphabetic. And embeddings <i>aren't</i> alphabetic and don't share the same constraints.<p>I recommend Judith Flanders' "A Place for Everything" as a both a history and survey of the constraints in sorting and organising information in an alphabetic language. It's also a fun read!<p>tl;dr why would we want an LLM do something as inefficiently as a human?</p>
]]></description><pubDate>Sat, 30 Aug 2025 12:31:11 +0000</pubDate><link>https://news.ycombinator.com/item?id=45074064</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=45074064</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=45074064</guid></item><item><title><![CDATA[New comment by quadhome in "Starship's Tenth Flight Test"]]></title><description><![CDATA[
<p>"Making the decision to have a child - it is momentous. It is to decide forever to have your heart go walking around outside your body." -- Elizabeth Stone</p>
]]></description><pubDate>Wed, 27 Aug 2025 10:32:39 +0000</pubDate><link>https://news.ycombinator.com/item?id=45037736</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=45037736</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=45037736</guid></item><item><title><![CDATA[New comment by quadhome in "The Missing Protocol: Let Me Know"]]></title><description><![CDATA[
<p>WebSub[1] has been a standard for real-time notification of changes for at least a decade.<p>[1] <a href="https://en.wikipedia.org/wiki/WebSub" rel="nofollow">https://en.wikipedia.org/wiki/WebSub</a></p>
]]></description><pubDate>Wed, 13 Aug 2025 11:11:12 +0000</pubDate><link>https://news.ycombinator.com/item?id=44887011</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=44887011</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=44887011</guid></item><item><title><![CDATA[New comment by quadhome in "HHS Winds Down mRNA Vaccine Development Under BARDA"]]></title><description><![CDATA[
<p>AIUI early transistor research was funded by public (defense) grants. And Bell Labs was definitely government <i>supported</i>, if not outright government funded.</p>
]]></description><pubDate>Wed, 06 Aug 2025 15:51:37 +0000</pubDate><link>https://news.ycombinator.com/item?id=44813643</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=44813643</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=44813643</guid></item><item><title><![CDATA[New comment by quadhome in "Second Variety, by Philip K. Dick (1953)"]]></title><description><![CDATA[
<p>Screamers (1995) is one of my favourite sci-fi movies and it's more or less The Secondary Variety in film form.<p>Beware: low ratings on Rotten Tomatoes, "frustrating close to being great."</p>
]]></description><pubDate>Sat, 12 Jul 2025 23:53:08 +0000</pubDate><link>https://news.ycombinator.com/item?id=44546256</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=44546256</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=44546256</guid></item><item><title><![CDATA[New comment by quadhome in "Domains I Love"]]></title><description><![CDATA[
<p><a href="https://cr.app" rel="nofollow">https://cr.app</a> is the time wasting microsite for the DTC toilet paper company Who Gives A Crap.</p>
]]></description><pubDate>Tue, 10 Jun 2025 05:31:23 +0000</pubDate><link>https://news.ycombinator.com/item?id=44232889</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=44232889</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=44232889</guid></item><item><title><![CDATA[New comment by quadhome in "GPS Needs to Toughen Up, or Get Trampled Down"]]></title><description><![CDATA[
<p><i>Galileo’s open service (civil-access) E1 signal incorporates public/private key encryption to digitally sign and authentify data. False Galileo signals from malicious forces are easily detected and rejected by GNSS receivers because they lack encryption watermarks. The feature, called Open Service-Navigation Message Authentication (OS-NMA), has been fully operational since August 2023.</i></p>
]]></description><pubDate>Wed, 21 May 2025 15:47:00 +0000</pubDate><link>https://news.ycombinator.com/item?id=44052745</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=44052745</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=44052745</guid></item><item><title><![CDATA[New comment by quadhome in "“The Mind in the Wheel” lays out a new foundation for the science of mind"]]></title><description><![CDATA[
<p>Physical latencies in distributed systems design. Calibration for input devices.  Block storage failures and RAID in general. Monitor refresh rates. Almost everything about audio. Rowhammer.</p>
]]></description><pubDate>Fri, 16 May 2025 18:36:41 +0000</pubDate><link>https://news.ycombinator.com/item?id=44008561</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=44008561</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=44008561</guid></item><item><title><![CDATA[New comment by quadhome in "Why agency and cognition are fundamentally not computational"]]></title><description><![CDATA[
<p>A map is not the territory.</p>
]]></description><pubDate>Thu, 15 May 2025 16:32:11 +0000</pubDate><link>https://news.ycombinator.com/item?id=43996690</link><dc:creator>quadhome</dc:creator><comments>https://news.ycombinator.com/item?id=43996690</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=43996690</guid></item></channel></rss>