Hacker News: resiros

New comment by resiros in "The Unreasonable Redundancy of Nature's Protein Folds"

resiros — Wed, 03 Jun 2026 16:20:40 +0000

> However, the point the article is making is that for different functions the same basic folds seem to be used again and again.

That's a basic fact in bio. Check the rossman fold page for example: https://en.wikipedia.org/wiki/Rossmann_fold it's a template used for many functions.

New comment by resiros in "The Unreasonable Redundancy of Nature's Protein Folds"

resiros — Wed, 03 Jun 2026 07:22:32 +0000

Evolution discovered a bunch of structural patterns at different layers (fragments, folds..) that are energetically favorable, versatile, easily foldable, robust to mutations and then kept reusing them. As a result it sampled more and more in these parts of the space. That's why the fold space is uneven.

Are there any folds and patterns that evolution evolution has not discovered that are also useful? I think Baker Group created a bunch of new folds. I'm not sure if they are as useful as the one discovered by Evolution. After all, Evolution had more compute power than us.

New comment by resiros in "Strace-ui, Bonsai_term, and the TUI renaissance"

resiros — Tue, 02 Jun 2026 10:15:58 +0000

I agree. The only reason I use TUI is because GUI are very slow with electron.

The only software that is as fast as TUI is the Zed IDE. Apparently they use Rust + their own built GUI toolkit with GPU rendering.

And apparently it's tightly coupled with Zed.

New comment by resiros in "I’ve joined Anthropic"

resiros — Tue, 19 May 2026 15:51:06 +0000

I think you are underestimating both the value of both projects (autoresearch and personal wiki) just because they are simple. I see both POCs for continuous learning / optmization on the harness layer, which in my opinion is a very interesting direction.

I think Andrej has the experience (and now ressources) to productionize this research into something very interesting.

p.s. called it

> Karpathy will help launch a new team focused on using Claude itself to accelerate pretraining research — an increasingly important frontier as AI companies race to automate parts of AI development. (https://www.axios.com/2026/05/19/anthropic-openai-karpathy-a...)

New comment by resiros in "I’ve joined Anthropic"

resiros — Tue, 19 May 2026 15:29:15 +0000

I don't think this is true. He strikes me as a person motivated by curiosity and interesting problems.

At Protocol: Building the Social Internet

resiros — Wed, 29 Apr 2026 16:20:56 +0000

Article URL: https://atproto.com/

Comments URL: https://news.ycombinator.com/item?id=47950575

Points: 94

# Comments: 41

New comment by resiros in "A name is succession, legacy and celebration in Japan's Kabuki theater"

resiros — Tue, 14 Apr 2026 08:42:56 +0000

Going to Kabuki was one of the most amazing experiences we had when visiting Japan. Although I am not a theater person, and the whole thing was in Japanese ,and we did not have the auto-translate tablets, we enjoyed it a lot. It was very beautiful, and funny.

I recommend to anyone visiting that part of the world.

New comment by resiros in "Can Claude Fly a Plane?"

resiros — Tue, 14 Apr 2026 08:35:32 +0000

I think you gave someone an idea for a new RL environment :) Probably it will be able to fly it in the next iteration.

New comment by resiros in "Delve – Fake Compliance as a Service"

resiros — Fri, 20 Mar 2026 17:39:33 +0000

This seems like a hit job by a competitor. Really ruthless.

> Two months ago, an email went out to a few hundred Delve clients informing them that Delve had leaked their audit reports, alongside other confidential information, through a Google spreadsheet that was publicly accessible.

Who leaked the audit reports? Who sent this email? Who is taking the time to write this analysis and kill the company?

In my opinion, the majority of the points in the article are no news. A compliance saas that offers templates for policies, all of them do. The AI is a chatbot, well who thought.

I think the main point is the collusion between delve and the auditors. Is the evidence for that clear?

New comment by resiros in "Don't post generated/AI-edited comments. HN is for conversation between humans"

resiros — Wed, 11 Mar 2026 20:10:13 +0000

Not sure I agree with the AI edited comments. Using AI to improve the readability and clarity is fine. Sometimes a well structured comment is much better than a braindump that reads like ramblings. And AI is quite good at it (and probably will get better). To make the point, here is how this comment would have looked if edited:

"I don't fully agree with banning AI-edited comments. Using AI to improve readability and clarity is a reasonable thing to do. A well-structured comment is often much better than a braindump that reads like rambling. AI is quite good at this, and it will probably get better. To illustrate the point, here is how this comment would have looked if edited"

New comment by resiros in "You need to rewrite your CLI for AI agents"

resiros — Thu, 05 Mar 2026 09:18:23 +0000

I don't follow the need to write CLIs for the agent. Why not use simply the API and document it well? The token difference between using an API and CLI is not that much, and models are trained to use REST APIs and understand their patterns, compared to your random CLI.

New comment by resiros in "Tailscale Peer Relays is now generally available"

resiros — Thu, 19 Feb 2026 11:16:19 +0000

I use netbird and can only recommend it

New comment by resiros in "Tailscale Peer Relays is now generally available"

resiros — Thu, 19 Feb 2026 11:15:16 +0000

Netbird is very good for my use case. Simple to set up, and just works.

New comment by resiros in "Anthropic officially bans using subscription auth for third party use"

resiros — Thu, 19 Feb 2026 11:04:48 +0000

It might simply be that it was not trained enough in Elixir RL environments compared to Gemini and gpt. I use it for both ts and python and it's certainly better than Gemini. For Codex, it depends on the task.

New comment by resiros in "Semantic ablation: Why AI writing is generic and boring"

resiros — Tue, 17 Feb 2026 16:56:27 +0000

I mean, no one is asking for artistic writing, just not some obvious AI slop. The fact that we all can now easily determine that some text has been written / edited by AI is already an issue. No amount of prompting can help.

New comment by resiros in "Semantic ablation: Why AI writing is generic and boring"

resiros — Tue, 17 Feb 2026 16:46:33 +0000

I wonder why AI labs have not worked on improving the quality of the text outputs. Is this as the author claims a property of the LLMs themselves? Or is there simply not much incentive to create the best writing LLM?

New comment by resiros in "Claude Code is being dumbed down?"

resiros — Wed, 11 Feb 2026 19:19:47 +0000

Honestly, just use OpenCode. It works with Claude Code Max, and the TUI is 100x better. The only thing that sucks is Compaction.

Entire: Open-source tool that pairs agent context to Git commits

resiros — Tue, 10 Feb 2026 17:51:52 +0000

Article URL: https://entire.io/

Comments URL: https://news.ycombinator.com/item?id=46963873

Points: 4

# Comments: 3

New comment by resiros in "Show HN: Agent-of-empires: OpenCode and Claude Code session manager"

resiros — Tue, 13 Jan 2026 09:04:12 +0000

This is quite nice but limited in that it is single-player. In my opinion, the next generation of AI agents will be multi-player. Ramp's background agent is a good example https://builders.ramp.com/post/why-we-built-our-background-a...

Making this multi-player + creating the right representation to collaborate with agents is in my opinion the next bottlenecks. I wrote a small article about my thoughts there https://x.com/mmabrouk_/status/2010803911486292154

New comment by resiros in "Python Workers redux: fast cold starts, packages, and a uv-first workflow"

resiros — Thu, 11 Dec 2025 08:31:26 +0000

Very interesting but the limitation on the libraries you can use is very strong.

I wonder if they plan to invest seriously into this?