Hacker News: rscho

New comment by rscho in "Review of Anti-Aging Drugs"

rscho — Mon, 18 Aug 2025 13:01:03 +0000

~1/10.000 patient-years is a non-concern ?! I hope you're not an epidemiologist.

New comment by rscho in "Review of Anti-Aging Drugs"

rscho — Sun, 17 Aug 2025 21:45:18 +0000

Metabolic acidosis. Not trivial at all.

New comment by rscho in "Review of Anti-Aging Drugs"

rscho — Sun, 17 Aug 2025 21:44:44 +0000

Which happily, is totally devoid of side effects.

New comment by rscho in "Review of Anti-Aging Drugs"

rscho — Sun, 17 Aug 2025 21:37:56 +0000

Amusingly, this was a very common if not the most common stance on this very website some time ago. Surely, don't look for assistance on the internet regarding memory issues.

New comment by rscho in "Review of Anti-Aging Drugs"

rscho — Sun, 17 Aug 2025 21:05:57 +0000

Don't come and spoil our nice individualism with populational effects, you filthy rationalist !

New comment by rscho in "Endoscopist deskilling risk after exposure to AI in colonoscopy"

rscho — Sun, 17 Aug 2025 20:43:41 +0000

Of course deskilling will happen. But marketing says the machine is more often right than the operator is, and people also want it (we can replace docs with AI today, yadda yadda). Soooo... to be expected? It's just that the machine has to work correctly, which is not on the endoscopist, right?

New comment by rscho in "Review of Anti-Aging Drugs"

rscho — Sun, 17 Aug 2025 20:20:18 +0000

You're absolutely right! This man's got horrible taste in drugs.

New comment by rscho in "Review of Anti-Aging Drugs"

rscho — Sun, 17 Aug 2025 20:17:54 +0000

How to hedge a bet 101:

1.you bet on risky stuff using something of value (money, health,...)

2.since you're unsure whether your bet will pay off, you bet some more on some other risky stuff, just to be sure.

BTW if you were wondering, of course all those proposed weird life-prolonging treatments are totally devoid of side-effects.

New comment by rscho in "Review of Anti-Aging Drugs"

rscho — Sun, 17 Aug 2025 20:08:10 +0000

Yes, although even for modern medicine curative and preventative strategies are very distinct. Sure, they'll give you pills to compensate for a problem you already have. But there are few meds that protect you against stuff you'll maybe catch in the future. Vaccines and antibiotics are obvious examples, but I'm not aware of many others. The rest of preventative strategies overwhelmingly consists in correcting deficits or excesses (calories, vitamins, sleep, exercise etc.)

New comment by rscho in "Review of Anti-Aging Drugs"

rscho — Sun, 17 Aug 2025 19:58:26 +0000

You've got horrible taste in cocktails.

New comment by rscho in "Review of Anti-Aging Drugs"

rscho — Sun, 17 Aug 2025 19:41:26 +0000

Surprisingly, many people seem to think that pushing a few random pills into a machine optimized over some million years of evolution will tune it so it works better. Go figure...

New comment by rscho in "Review of Anti-Aging Drugs"

rscho — Sun, 17 Aug 2025 19:35:28 +0000

Lack of pharmacology background doesn't seem like the biggest issue when extrapolating from mouse to human.

New comment by rscho in "Review of Anti-Aging Drugs"

rscho — Sun, 17 Aug 2025 19:33:29 +0000

Truth be told, none of either prescription or OTC stuff has any solid research backing it. Some people, especially on HN are obsessed with living long and are always prompt to try the weirdest experimental stuff. Reasonable people should remember what the COVID period was on this website, and act accordingly...

New comment by rscho in "Coalton Playground: Type-Safe Lisp in the Browser"

rscho — Wed, 13 Aug 2025 20:56:13 +0000

Statically checked macros are useful to introduce new syntax at no runtime cost.

New comment by rscho in "United Airlines grounds flights after system meltdown"

rscho — Thu, 07 Aug 2025 14:11:01 +0000

Beatings will continue until morale improves.

New comment by rscho in "Ozempic shows anti-aging effects in trial"

rscho — Thu, 07 Aug 2025 09:59:13 +0000

> silly unless your general stance is that you won't take any medication until that specific formulation has been on the market for decades

Yes, I'd argue that this is the default stance for many healthcare professionals.

New comment by rscho in "Ozempic shows anti-aging effects in trial"

rscho — Thu, 07 Aug 2025 07:58:40 +0000

Ozempic is very recent. Given the volume of prescription, the probability of problematic side-effect in the short-to-medium term indeed seems low. But it sill is too early to say whether ozempic really isn't problematic. Let's hope so.

New comment by rscho in "Ozempic shows anti-aging effects in trial"

rscho — Wed, 06 Aug 2025 15:12:27 +0000

Yeah, something like omeprazole.

New comment by rscho in "Ozempic shows anti-aging effects in trial"

rscho — Wed, 06 Aug 2025 13:53:53 +0000

Ibuprofen ? That's really not something I'd have expected to end up in someone's 'healthy stuff' list. Ibuprofen increases the risk of cardiac event and is a common precipiting factor in renal failure. Most antibiotics also do not do only good things. The list is too long to write here. Side effects profiles change with research and marketing developments, but thinking these drugs are only beneficial is a bit over the top.

Edit: I forgot. Ibuprofen also causes (non trivial) stomach bleeding and increases blood pressure. And many other things too.

New comment by rscho in "Build Your Own Lisp"

rscho — Wed, 06 Aug 2025 08:32:52 +0000

Ok, so I am sorry but this is an extremely uninformed take. Please have a look around in Racket's documentation before going any further: https://docs.racket-lang.org/