Hacker News: s3tt3mbr1n1

New comment by s3tt3mbr1n1 in "Ask HN: Any interesting niche hobbies?"

s3tt3mbr1n1 — Wed, 08 Apr 2026 20:41:27 +0000

Very interested to hear more. Do you live in an (old) city or more rurally?

New comment by s3tt3mbr1n1 in "Fermented foods shaped human biology"

s3tt3mbr1n1 — Thu, 26 Mar 2026 21:06:10 +0000

Replying to see if anyone has a foolproof solution.

My next attempt will include better, windmill milled flour.

New comment by s3tt3mbr1n1 in "Self-replicating RNA discovered of only 45 nucleotides long"

s3tt3mbr1n1 — Fri, 13 Feb 2026 09:02:56 +0000

Original title (too long for submission): “A small polymerase ribozyme that can synthesize itself and its complementary strand“

Abstract: The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural complexity impede self-replication and preclude their spontaneous emergence. Here we describe QT45: a 45-nucleotide polymerase ribozyme, discovered from random sequence pools, that catalyzes general RNA-templated RNA synthesis using trinucleotide triphosphate (triplet) substrates in mildly alkaline eutectic ice. QT45 can synthesize both its complementary strand using a random triplet pool at 94.1% per-nucleotide fidelity, and a copy of itself using defined substrates, both with yields of ~0.2% in 72 days. The discovery of polymerase activity in a small RNA motif suggests that polymerase ribozymes are more abundant in RNA sequence space than previously thought.

Self-replicating RNA discovered of only 45 nucleotides long

s3tt3mbr1n1 — Fri, 13 Feb 2026 09:01:07 +0000

Article URL: https://www.science.org/doi/10.1126/science.adt2760

Comments URL: https://news.ycombinator.com/item?id=47000592

Points: 4

# Comments: 3

New comment by s3tt3mbr1n1 in "Ask HN: What are you working on? (February 2026)"

s3tt3mbr1n1 — Mon, 09 Feb 2026 08:02:31 +0000

This is sick, great job!

New comment by s3tt3mbr1n1 in "Apple TV+ free first weekend of 2025"

s3tt3mbr1n1 — Tue, 31 Dec 2024 16:40:16 +0000

Smart move by Apple. I thoroughly enjoyed the first season of Severance and can recommend it to everyone.

New comment by s3tt3mbr1n1 in "Model Context Protocol"

s3tt3mbr1n1 — Mon, 25 Nov 2024 16:42:04 +0000

First, thank you for working on this.

Second, a question. Computer Use and JSON mode are great for creating a quasi-API for legacy software which offers no integration possibilities. Can MCP better help with legacy software interactions, and if so, in what ways?

New comment by s3tt3mbr1n1 in "OmniParser for Pure Vision Based GUI Agent"

s3tt3mbr1n1 — Fri, 25 Oct 2024 22:27:46 +0000

Has anyone gotten this to work?

Copying the repo and downloading the models through HuggingFace or manually does not seem to work, you get errors indicating missing files.

New comment by s3tt3mbr1n1 in "The Intelligence Age"

s3tt3mbr1n1 — Mon, 23 Sep 2024 17:44:21 +0000

For this reason I read Andrew Yang’s “The War on Normal People”. Besides UBI and “social credits”, I don’t see him offer that many other solutions to this problem. UBI also still needs to be proven as far as I’m aware.

When o1 was released, I ran an internal eval and saw it plainly outperforming our highly educated colleagues. I had goosebumps, and haven’t been able to sleep well for days. This will dramatically impact society in 2-5 years.

Do you know of any relevant material related to this?

New comment by s3tt3mbr1n1 in "Zed AI"

s3tt3mbr1n1 — Tue, 20 Aug 2024 19:13:19 +0000

Interesting that this seems to be the announcement of Anthropic's Copilot alternative:

> A private beta of the Claude 3.5 Sonnet's new Fast Edit Mode, optimized for text editing. This upcoming mode achieves unprecedented speed in transforming existing text, enabling near-instantaneous code refactoring and document editing at scale.

New comment by s3tt3mbr1n1 in "Uncomfortable truth: How close is "positivity culture" to delusion and denial?"

s3tt3mbr1n1 — Mon, 01 Jul 2024 12:30:17 +0000

Sounds like the Golden Mean, or Aristotle's moral virtues. [0]

[0] https://en.wikipedia.org/wiki/Golden_mean_(philosophy)#Arist...

New comment by s3tt3mbr1n1 in "When new hires get paid more, top performers resign first"

s3tt3mbr1n1 — Fri, 29 Mar 2024 19:40:11 +0000

Anything you would recommend, specifically for salary negotiations?

New comment by s3tt3mbr1n1 in "When new hires get paid more, top performers resign first"

s3tt3mbr1n1 — Fri, 29 Mar 2024 19:39:35 +0000

That’s very insightful and the argument I would expect if I were to start discussions about salary. How would you counter this?

I would also say I’m more qualified for the job than those that are applying now, so I’m not sure if this really is applicable to me.

New comment by s3tt3mbr1n1 in "When new hires get paid more, top performers resign first"

s3tt3mbr1n1 — Fri, 29 Mar 2024 18:17:28 +0000

I’m in the unique situation where I’m hiring my replacement after having made a promotion. I know they will make (substantially) more than me. How would I negotiate a matching or superior salary?

New comment by s3tt3mbr1n1 in "Yann LeCun does not possess an internal monologue"

s3tt3mbr1n1 — Thu, 14 Mar 2024 22:33:24 +0000

I feel like this might explain (and validate?) his conservative stance towards generative LLMs leading to AGI/ASI. What do you think?

Yann LeCun does not possess an internal monologue

s3tt3mbr1n1 — Thu, 14 Mar 2024 22:33:24 +0000

Article URL: https://twitter.com/ylecun/status/1768354396142706906

Comments URL: https://news.ycombinator.com/item?id=39709732

Points: 4

# Comments: 15

New comment by s3tt3mbr1n1 in "First look at Microsoft 365 Copilot"

s3tt3mbr1n1 — Fri, 15 Dec 2023 13:57:02 +0000

It’s not recommended to finetune models on content that was not in the training set.

Finetuning should be reserved for desired behavior of the LLM, not to add new knowledge. For that, RAG is better suited.