Hacker News: sakai

New comment by sakai in "The FDA's notes from its visit to Theranos' labs don't look good"

sakai — Wed, 28 Oct 2015 12:30:48 +0000

Well, the troubling thread here is that that may not be posssible using the amount of blood Theranos collects. Then the question becomes not only why is their valuation so high (which the public doesn't need to care too much about) but "how well do these traditional tests work with Theranos samples?"

That the answer could be "not very well" (and we haven't heard otherwise) is what's most troubling to me.

The Trans-Everything CEO

sakai — Wed, 10 Sep 2014 01:30:32 +0000

Article URL: http://nymag.com/news/features/martine-rothblatt-transgender-ceo/index8.html#print

Comments URL: https://news.ycombinator.com/item?id=8294412

Points: 3

# Comments: 0

1284 Slides Prepared by Ryan Allis for 30th Birthday

sakai — Fri, 15 Aug 2014 05:42:46 +0000

Article URL: http://www.businessinsider.com/ryan-allis-2014-8

Comments URL: https://news.ycombinator.com/item?id=8181126

Points: 3

# Comments: 0

New comment by sakai in "Ask HN: Who isn't in the software industry/not a hacker?"

sakai — Fri, 08 Aug 2014 21:48:32 +0000

Hey – working on a startup in the space and am very interested in talking with somebody working in infection control. If it's of interest, please send me an email (in my profile).

And would love to hear your plans too!

New comment by sakai in "Show HN: Aptible – Deployment platform to automate HIPAA compliance"

sakai — Fri, 25 Jul 2014 19:18:25 +0000

Yes, and you've promoted Catalyze.io several times on Twitter in the past month. So let's not feign too much outrage please.

New comment by sakai in "Show HN: Simple interactive SQL exploration with IPython/Pandas"

sakai — Mon, 09 Jun 2014 04:32:19 +0000

OP here. This was just a little module that I found very useful in quickly exploring large, unfamiliar SQL databases and their associated business logic.

It's fairly rudimentary feature-wise, but has worked well for me. Happy to answer any questions.

Show HN: Simple interactive SQL exploration with IPython/Pandas

sakai — Mon, 09 Jun 2014 01:08:09 +0000

Article URL: https://github.com/boydgreenfield/query/

Comments URL: https://news.ycombinator.com/item?id=7866551

Points: 22

# Comments: 3

Google Runs All Software In Containers

sakai — Mon, 02 Jun 2014 19:07:12 +0000

Article URL: http://www.enterprisetech.com/2014/05/28/google-runs-software-containers/

Comments URL: https://news.ycombinator.com/item?id=7835307

Points: 2

# Comments: 0

Getting a job at a top university will not make you a better researcher

sakai — Fri, 16 May 2014 04:38:56 +0000

Article URL: http://www.economist.com/news/science-and-technology/21601811-getting-job-top-university-will-not-make-you-better-researcher-why-climb

Comments URL: https://news.ycombinator.com/item?id=7753766

Points: 2

# Comments: 0

New comment by sakai in "Show HN: Helix I/O – Ultrafast genomic search"

sakai — Mon, 12 May 2014 20:29:13 +0000

Ah – well to clarify, we're performing exact match lookups on individual k-mers (k-length genetic strings), and then computing a classification result from those exact searches.

New comment by sakai in "Show HN: Helix I/O – Ultrafast genomic search"

sakai — Mon, 12 May 2014 20:09:30 +0000

Yes, we're building out the features to make it easy to use with your own corpus. I'll follow up by email, but can you clarify what species identification issues you're seeing? (Would like to double check and get it fixed asap if there's a problem).

Thx!

New comment by sakai in "Show HN: Helix I/O – Ultrafast genomic search"

sakai — Mon, 12 May 2014 19:56:41 +0000

That was an attempt to say (without resorting to Big Oh notation) that the data structures and algorithms we're working on provide O(1) lookups that take a fixed amount of time regardless of the reference / dataset size. Does that make more sense?

New comment by sakai in "Show HN: Helix I/O – Ultrafast genomic search"

sakai — Mon, 12 May 2014 19:13:40 +0000

Hope it was clear that you can test it out with some small FASTA or FASTQ files now (just drag onto the upload icon).

And yes, we'd be happy to discuss your use case and get you set up with something. Just shoot me a note at nick at helix dot io and we can follow up off thread.

New comment by sakai in "Show HN: Helix I/O – Ultrafast genomic search"

sakai — Mon, 12 May 2014 18:34:18 +0000

In principle, some of them can be yes. Though genetic reference datasets tend to be much larger than, e.g., codebases -- and therefore require different approaches.

One of the core things we're working on is a data structure for more efficient, constant-time sequence lookups, and we've definitely thought of some non-bioinformatics use cases as well. Happy to answer any more specific questions by email too (in my profile)!

New comment by sakai in "Show HN: Helix I/O – Ultrafast genomic search"

sakai — Mon, 12 May 2014 18:20:27 +0000

cfontes – Yes, that's definitely another use case of the underlying technology, though please note that the database loaded for the demo only include archaeal, bacterial and viral genomes (so you'd have a very hard time getting a hit on sugarcane sequences!).

(This is nkrumm's and my project)

New comment by sakai in "BasicCoin, a cryptocurrency in less than 600 lines of Python"

sakai — Thu, 08 May 2014 04:30:04 +0000

Honest suggestion: Change the tagline to "less than 1000 lines" or exclude the GUI or whatever, but don't just not include line breaks anywhere.

You have 7 very sensible, and indeed admirable, style guidelines and while no line breaks only clearly violates one of them (PEP8), it's not really in the spirit of the others either. I opened gui.py and immediately was overwhelmed, rather than compelled to dive in and digest your small codebase.

Antivirus is dead. Meet the next-generation of anti-hacker tools.

sakai — Wed, 07 May 2014 20:53:18 +0000

Article URL: http://www.fastcompany.com/3030075/whos-next/antivirus-is-dead-meet-the-next-generation-of-anti-hacker-tools

Comments URL: https://news.ycombinator.com/item?id=7712593

Points: 2

# Comments: 1

New comment by sakai in "Show HN: WriterKata – a site for writers to practice their craft"

sakai — Mon, 05 May 2014 05:36:37 +0000

Got it. Apparently I tried with a very short sentence! Thanks!

New comment by sakai in "Show HN: WriterKata – a site for writers to practice their craft"

sakai — Mon, 05 May 2014 02:14:25 +0000

Very cool.

One question – I noticed that you're doing some validation of the inputs (i.e., I can't seem to submit a sentence without a period) – could you explain the reasoning for this?

On the one hand, it seems fairly constraining (and probably comes with a few unfortunate edge cases). On the other, perhaps that's the benefit of the kata philosophy.

New comment by sakai in "Y Combinator Bets on Biotech"

sakai — Wed, 23 Apr 2014 21:42:36 +0000

Ah ha. Thanks for the heads up!

(Looking over the application again now...)