I've written about the Australian clinical trial system and the reforms I think India needs to accelerate our slow and archaic framework twice recently:

1) https://www.infinitesunrise.com/p/we-must-accelerate-clinica...

2) https://economictimes.indiatimes.com/opinion/et-commentary/a...

PVX-001 is a broadly-protective COVID-19 vaccine candidate intended to protect against new variants of SARS-CoV-2 even as the virus mutates. It is built on our RNA-encoded virus-like particle (VLP) architecture to elicit a broad & potent immune response.

Our lipid nanoparticle (LNP) formulation, based on our own novel ionizable lipid PVXL-150, keeps the vaccine stable at 2-8 °C, regular refrigerator temperatures, for at least 9 months, rather than the -20 or -80 °C required by the first-generation mRNA vaccines approved for COVID-19. This will make it far easier to distribute the vaccine in developing countries.

The vaccine was largely funded by Vitalik Buterin's scientific investment fund Balvi -- in collaboration with them, we've made a commitment to making this vaccine open-source. Once the Phase I trial of PVX-001 concludes, we will open-source the design and manufacturing information needed for others to produce and build on it, and we will not enforce our intellectual property rights against anyone who uses it to make vaccines against any betacoronavirus -- the viral genus that includes SARS-CoV-2, SARS-CoV, and MERS-CoV.

We are doing this because SARS-CoV-2 and its close cousins remain a substantial pandemic risk. In just the past few decades, they have caused one major epidemic (SARS), one close call (MERS), and one global pandemic that killed millions. The designs developed after the original SARS outbreak gave the first generation of COVID-19 vaccines a crucial head start in 2020. We want humanity to have an even better head start next time: a broadly-protective, refrigerator-stable vaccine that any scientist, vaccine producer, or member of the public, located anywhere, can improve, adapt to their needs, and manufacture without having to worry about IP.

Comments URL: https://news.ycombinator.com/item?id=37206431

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Pashi is building the operating system for manufacturing. We already work with some of the largest manufacturers in the world, and our software is being brought to bear against some of the thorniest problems that plague the most mission-critical high-volume production processes ever constructed.

We're currently a very small, very technical team spread across India, Europe, and the US, and we're looking for folks with strong backgrounds in programming languages and compilers to help us build better programming abstractions for physical processes.

Email soham@pashi.com with a paragraph-length description of any relevant experience if you're interested.

Comments URL: https://news.ycombinator.com/item?id=24776163

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