<rss version="2.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Hacker News: strbean</title><link>https://news.ycombinator.com/user?id=strbean</link><description>Hacker News RSS</description><docs>https://hnrss.org/</docs><generator>hnrss v2.1.1</generator><lastBuildDate>Mon, 15 Jun 2026 00:40:56 +0000</lastBuildDate><atom:link href="https://hnrss.org/user?id=strbean" rel="self" type="application/rss+xml"></atom:link><item><title><![CDATA[New comment by strbean in "CRISPR tech selectively shreds cancer cells, including "undruggable" cancers"]]></title><description><![CDATA[
<p>Interesting, thanks for the info!<p>Another question: how does this approach compare to trying to repair the pathogenic variants in the cancer? I asked here about that approach recently and the response was mainly about delivery difficulties: <a href="https://news.ycombinator.com/item?id=48285386">https://news.ycombinator.com/item?id=48285386</a></p>
]]></description><pubDate>Fri, 12 Jun 2026 20:47:06 +0000</pubDate><link>https://news.ycombinator.com/item?id=48509256</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48509256</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48509256</guid></item><item><title><![CDATA[New comment by strbean in "CRISPR tech selectively shreds cancer cells, including "undruggable" cancers"]]></title><description><![CDATA[
<p>> Indeed, there's no "be a better/stronger cancer and spread more effectively to more hosts" the way there is with bacteria or a virus.<p>The rare exception: <a href="https://en.wikipedia.org/wiki/Clonally_transmissible_cancer" rel="nofollow">https://en.wikipedia.org/wiki/Clonally_transmissible_cancer</a></p>
]]></description><pubDate>Fri, 12 Jun 2026 18:46:39 +0000</pubDate><link>https://news.ycombinator.com/item?id=48507928</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48507928</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48507928</guid></item><item><title><![CDATA[New comment by strbean in "CRISPR tech selectively shreds cancer cells, including "undruggable" cancers"]]></title><description><![CDATA[
<p>Depending on how the LNPs are designed, would resistance also potentially cripple the cancer cells? Like, it stops surfacing some cholesterol receptor because the drug is being delivered by LNPs that target that receptor, and now the cell is starved for cholesterol?<p>I've heard about drug resistance in bacteria leading to slower growth / reduced virulence. Maybe the same would occur with cancers. A drug that could effectively switch an aggressive cancer into a slow-growing one wouldn't be the worst thing.</p>
]]></description><pubDate>Fri, 12 Jun 2026 18:45:09 +0000</pubDate><link>https://news.ycombinator.com/item?id=48507905</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48507905</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48507905</guid></item><item><title><![CDATA[New comment by strbean in "Are you expected to run five Python type-checkers now?"]]></title><description><![CDATA[
<p>_RelationshipBackPopulatesArgument = Union[
     str,
     PropComparator[Any],
     Callable[[], Union[str, PropComparator[Any]]],
 ]</p>
]]></description><pubDate>Mon, 08 Jun 2026 21:06:31 +0000</pubDate><link>https://news.ycombinator.com/item?id=48452071</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48452071</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48452071</guid></item><item><title><![CDATA[New comment by strbean in "Stop Killing Games"]]></title><description><![CDATA[
<p>Seems like that's... one more substantive meeting?<p>First link is announcing the initiative was submitted, second is a private meeting where the initiative was presented to the comission by the organizers.<p>Then there was a public meeting on 16 April 2026 and a public meeting on 20 May 2026.<p>Is there a specific part of one of those meetings that indicates they want to go a different direction than the California bill?<p>From the last link:<p>> If designed responsibly, most games that connect to the internet can operate indefinitely without publisher support. This has been a customer expectation for over 50 years. We are open to any solution that solves the problem. We are flexible on specifics and implementation by publishers. We understand that not all game features may be operable in a discontinued game. We are not seeking ongoing support from publishers after a game has been discontinued<p>This sounds like the California bill would address these issues.<p>edit: Particularly, I'm wondering if there is any serious push for release of binaries / source code prior to the end-of-life of a game, which seems to be of particular concern.</p>
]]></description><pubDate>Wed, 03 Jun 2026 22:27:13 +0000</pubDate><link>https://news.ycombinator.com/item?id=48390992</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48390992</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48390992</guid></item><item><title><![CDATA[New comment by strbean in "Stop Killing Games"]]></title><description><![CDATA[
<p>If a game is popular enough for anyone to care, some turbonerd will get the server running on a massive cloud instance, and then people will be able to play the game.<p>Fans have reverse-engineered and stood up servers for tons of games with no access to the server binaries. The idea that they wouldn't figure it out when given much better resources (server binaries or source code) is crazy.</p>
]]></description><pubDate>Wed, 03 Jun 2026 21:14:26 +0000</pubDate><link>https://news.ycombinator.com/item?id=48390169</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48390169</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48390169</guid></item><item><title><![CDATA[New comment by strbean in "Stop Killing Games"]]></title><description><![CDATA[
<p>> but not the EU which is currently being drafted (in a different direction)<p>Where can we find information about the direction the EU is going on this? AFAICT there has just been one meeting on the topic?</p>
]]></description><pubDate>Wed, 03 Jun 2026 21:04:51 +0000</pubDate><link>https://news.ycombinator.com/item?id=48390019</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48390019</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48390019</guid></item><item><title><![CDATA[New comment by strbean in "SQLite is all you need for durable workflows"]]></title><description><![CDATA[
<p>Imagine if every tweet had to go through a one-at-a-time queue before being persisted. There's about 6000 tweets per second, so you would have to be able to save them at <0.17ms per tweet or else you would become backlogged. If you are getting backlogged, you have to buffer those incoming tweets somewhere until they can be writted, and eventually that buffer gets full and you start losing tweets.</p>
]]></description><pubDate>Fri, 29 May 2026 20:00:25 +0000</pubDate><link>https://news.ycombinator.com/item?id=48328424</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48328424</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48328424</guid></item><item><title><![CDATA[New comment by strbean in "The Ballad of TIGIT"]]></title><description><![CDATA[
<p>So for masses of solid tissue, we can't effectively deliver the payload to all the cells?<p>How about for lymphomas?</p>
]]></description><pubDate>Tue, 26 May 2026 23:28:19 +0000</pubDate><link>https://news.ycombinator.com/item?id=48287411</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48287411</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48287411</guid></item><item><title><![CDATA[New comment by strbean in "Opaque Types in Python"]]></title><description><![CDATA[
<p>> You'll note that even Java now recognises that "public static void main(String[] args)" was pointless ceremony.<p>There is still the part of the ceremony that actually mattered: having a single entrypoint instead of the option to litter side effects throughout the file and having those side effects execute automatically on import.<p>> It sucks, but what's the alternative?<p>3.0 was a big missed opportunity to kill a lot of the deprecated cruft.</p>
]]></description><pubDate>Tue, 26 May 2026 23:18:39 +0000</pubDate><link>https://news.ycombinator.com/item?id=48287350</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48287350</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48287350</guid></item><item><title><![CDATA[New comment by strbean in "The Ballad of TIGIT"]]></title><description><![CDATA[
<p>What's the status of just using CRISPR to fix pathogenic variants?</p>
]]></description><pubDate>Tue, 26 May 2026 20:14:57 +0000</pubDate><link>https://news.ycombinator.com/item?id=48285386</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48285386</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48285386</guid></item><item><title><![CDATA[New comment by strbean in "CISA Admin Leaked AWS GovCloud Keys on GitHub"]]></title><description><![CDATA[
<p>Plug for my buddy's project: <a href="http://agentsh.org/" rel="nofollow">http://agentsh.org/</a><p>Block agents from misbehaving at the OS level instead of asking them to behave.</p>
]]></description><pubDate>Wed, 20 May 2026 00:52:29 +0000</pubDate><link>https://news.ycombinator.com/item?id=48201683</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48201683</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48201683</guid></item><item><title><![CDATA[New comment by strbean in "Venom and hot peppers offer a key to killing resistant bacteria"]]></title><description><![CDATA[
<p>See also <a href="https://en.wikipedia.org/wiki/Double-stranded_RNA_activated_caspase_oligomerizer" rel="nofollow">https://en.wikipedia.org/wiki/Double-stranded_RNA_activated_...</a><p>This one is quite tinfoil-hat inspiring, as the research was moved to defense-focused Draper Labs and then immediately disappeared.</p>
]]></description><pubDate>Mon, 11 May 2026 18:28:53 +0000</pubDate><link>https://news.ycombinator.com/item?id=48098773</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48098773</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48098773</guid></item><item><title><![CDATA[New comment by strbean in "Software engineering may no longer be a lifetime career"]]></title><description><![CDATA[
<p>I know a an accomplished CS professor, ACM fellow, cited in Knuth's TAOCP (as well as being an easter egg!), who still hunt-and-pecks. In fact, hunt-an-pecks <i>incredibly slowly</i>.<p>Seeing him type really reinforced this idea.</p>
]]></description><pubDate>Mon, 11 May 2026 18:04:30 +0000</pubDate><link>https://news.ycombinator.com/item?id=48098419</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48098419</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48098419</guid></item><item><title><![CDATA[New comment by strbean in "CUDA-oxide: Nvidia's official Rust to CUDA compiler"]]></title><description><![CDATA[
<p>A lot of really good reasons:<p>1) Higher level code is easier for <i>LLMs</i> to review and iterate upon. The more the intent is clear from the code, the easier it is for humans and LLMs to work with.<p>2) LLMs get stuck or fail to solve a problem sometimes. It is preferable to have artifacts that humans can grok without the massive extra effort of parsing out assembly code.<p>3) Assembly code varies massively across targets. We want provable, deterministic transformation from the intent (specified in a higher level language) to the target assembly language. LLMs can't reliably output many artifacts for different platforms that behave the same.<p>4) Hopefully, we are still reviewing the code output by LLMs to <i>some extent</i>.</p>
]]></description><pubDate>Mon, 11 May 2026 17:40:57 +0000</pubDate><link>https://news.ycombinator.com/item?id=48098090</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=48098090</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=48098090</guid></item><item><title><![CDATA[New comment by strbean in "“Why not just use Lean?”"]]></title><description><![CDATA[
<p>Well, assembly languages are generally Turing complete. Not sure what the parallel would be in proof engines.</p>
]]></description><pubDate>Mon, 27 Apr 2026 18:02:50 +0000</pubDate><link>https://news.ycombinator.com/item?id=47925024</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=47925024</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47925024</guid></item><item><title><![CDATA[New comment by strbean in "Simulacrum of Knowledge Work"]]></title><description><![CDATA[
<p>Ironic, you've got some typos but make a good point :)</p>
]]></description><pubDate>Sun, 26 Apr 2026 05:48:58 +0000</pubDate><link>https://news.ycombinator.com/item?id=47907703</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=47907703</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47907703</guid></item><item><title><![CDATA[New comment by strbean in "My audio interface has SSH enabled by default"]]></title><description><![CDATA[
<p>Damn, maybe I can throw an agent at trying to unlock IMEI spoofing on my Unifi LTE modem. That one guy on twitter who does all the LTE modem unlocking never replied to my tweet :(</p>
]]></description><pubDate>Fri, 24 Apr 2026 21:32:26 +0000</pubDate><link>https://news.ycombinator.com/item?id=47896068</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=47896068</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47896068</guid></item><item><title><![CDATA[New comment by strbean in "I cancelled Claude: Token issues, declining quality, and poor support"]]></title><description><![CDATA[
<p>I was recently introduced to the term "vcware", ala shareware or vaporware, to describe these products. "Don't use that, it's vcware, enshitification is coming soon."</p>
]]></description><pubDate>Fri, 24 Apr 2026 17:15:20 +0000</pubDate><link>https://news.ycombinator.com/item?id=47893116</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=47893116</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47893116</guid></item><item><title><![CDATA[New comment by strbean in "We found a stable Firefox identifier linking all your private Tor identities"]]></title><description><![CDATA[
<p>There's a pretty big difference between:<p>1) wanting functionality that isn't provided and working around that<p>and<p>2) restoring such functionality in the face of countermeasures<p>The absence of functionality isn't a clear signal of intent, while countermeasures against said functionality is.<p>And then there is the distinction between the intent of the software publisher and the intent of the user. There is a big ethical difference between "Mozilla doesn't want advertisers tracking their users" and "those users don't want to be tracked". If these guys want to draw the line at "if there is a signal from the user that they want privacy, we won't track them", I think that's reasonable.</p>
]]></description><pubDate>Wed, 22 Apr 2026 22:20:09 +0000</pubDate><link>https://news.ycombinator.com/item?id=47870060</link><dc:creator>strbean</dc:creator><comments>https://news.ycombinator.com/item?id=47870060</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=47870060</guid></item></channel></rss>