- Some channels being affected more than others

- Likes remaining stable

- Revenue remaining stable

Could be explained by Youtube only counting non-adblocked views.

Perhaps an attempt to align Youtube's goals with creators' goals. If we don't get revenue then you don't either.

https://gitlab.com/cybears/fall-of-cybeartron/-/tree/master/...

Comments URL: https://news.ycombinator.com/item?id=44486115

Points: 4

# Comments: 1

I’ve just had a poorly thought out mild epiphany realizing what’s been staring me (and I’m sure everyone else) in the face: There is a huge burden of simple care tasks assisting people with transferring, mobility, dressing, showering, feeding, memory, medications etc.

Individually: The carer role is hard, physical, foul, violent, confronting, and worst of all 24/7.

Systemically: Half of the health system is clogged full of people admitted for social / care issues rather than medical issues. The population is aging and people are living longer with more severe deficits. There is a huge volume of exploited laborers keeping the system afloat.

It’s almost certainly a technical impossibility to solve a fraction of these problems and a large proportion of them likely need socially acceptable and safe human-robot interactions. However, a brilliant / affordable solution to getting grandpa out of bed or wiping his butt or engaging his mind could dramatically improve care timeliness, quality, safety, frequency, etc. and revolutionize parts of industries.

If you’re an entrepreneur looking for ripe territory consider literally any problem in aged / disability / nursing care.

TL;DR less hype / investment in self driving cars and AI that can solve esoteric BAR exams and more focus on helping grandpa safely stand and walk to the bathroom.

Comments URL: https://news.ycombinator.com/item?id=40951324

Points: 130

# Comments: 137

n+60 (is now + 60m)

n-10 (is 10m ago)

t+1 (is today + 1d)

w+2 (is two weeks from now)

m+12 (is 12 months from now)

I'm from a different country but these exams are the minimum standard to demonstrate a doctor is safe prior to interacting with patients. To be really explicit, the core competency being assessed is identifying potentially serious situations and answering the same way every time: "I WOULD CALL FOR HELP" +/- principles of basic care.

The benchmark for doctors actually making decisions about patient care are the assessments to become fully qualified consultants in a each specialty.

Again, to be really explicit don't confuse a test for "doctor won't immediately kill someone and commence reasonable first steps" with an actual "doctor with years of experience and subspecialty training who regularly makes decisions about patient care".

This guy[0] studies total average energy expenditure over time and demonstrates that an athlete undertaking intense regular exercise uses marginally more energy over time than someone sitting on a couch all day. The hypothesis being that the athlete is conserving energy by down-regulating baseline metabolic and inflammatory processes when at rest.

Disappointing news for "exercise causes dramatic weight loss" but encouraging news for "exercise is anti-cancer" (a correlation demonstrated many times I believe).

[0] https://www.science.org/content/article/scientist-busts-myth...

1. On DXM being an NMDA antagonist: At high concentration DXM is an NMDA antagonist and AXS-05 does dramatically increases DXM concentration [0] (slide 6). It is not clear to me why we should "ignore anyone" who makes this comparison?

2. On AXS-05 having a wide array of receptor targets: Almost all psychoactive drugs have some affinity for many receptors (just wikipedia any anti-psychotic e.g. [1]). Are any of the targets mentioned clinically significant at therapeutic concentrations?

[0] https://axsometherapeuticsinc.gcs-web.com/static-files/4a508... [1] https://en.wikipedia.org/wiki/Olanzapine

“Amazing new free open source standard freeing us all from closed / licensed tyranny”

vs.

“Giant corporation arriving late to standards competition hides behind “open source” as it uses it’s dominance to force fragmentation on everyone else”

My starter comment is this: whenever a new “open” project is proposed it should be independently evaluated as “good” as though it were closed source and the competitor open. Is “open-ness” being abused by companies when they find themselves in a market position they don’t like?

Comments URL: https://news.ycombinator.com/item?id=32949118

Points: 2

# Comments: 1

This study appears to show that fasting is related to inducing the gene Slc25a51 and improving those factors.

I guess this contributes to the body of science around the potential health benefits of fasting.

Comments URL: https://news.ycombinator.com/item?id=31386914

Points: 4

# Comments: 1

Perhaps something like introducing tumour suppressor genes to every cell. They’ll have no effect on healthy cells yet detect “badness” in cancerous cells and terminate them.

Morpheus: “no Neo, I’m trying to tell you that when you’re ready you won’t have to”

Altering the DNA is unnecessary if you can control the expression of genes or add additional genetic material later in the DNA->RNA->protein process. mRNA vaccines are already a great example of this. Another example might be the cystic fibrosis therapy Trikafta.