Hacker News: turkeytotal

New comment by turkeytotal in "SyntheMol-RL: reinforcement learning framework for designing novel antibiotics"

turkeytotal — Sat, 31 May 2025 19:30:37 +0000

> Today we show that our AI designed new molecule, synthecin, stops drug-resistant S. aureus MRSA in mouse model

> We created synthecin w/ SyntheMol-RL, our new RL generative AI. All open source.

https://x.com/james_y_zou/status/1924506075312894253

https://github.com/swansonk14/SyntheMol

SyntheMol-RL: reinforcement learning framework for designing novel antibiotics

turkeytotal — Sat, 31 May 2025 19:30:37 +0000

Article URL: https://www.biorxiv.org/content/10.1101/2025.05.17.654017v1

Comments URL: https://news.ycombinator.com/item?id=44146471

Points: 1

# Comments: 1

Google is the only search engine that works on Reddit now, thanks to AI deal

turkeytotal — Wed, 24 Jul 2024 13:41:22 +0000

Article URL: https://www.404media.co/google-is-the-only-search-engine-that-works-on-reddit-now-thanks-to-ai-deal/

Comments URL: https://news.ycombinator.com/item?id=41057033

Points: 515

# Comments: 356

New comment by turkeytotal in "US Navy set off a 40k-pound explosive to test its new supercarrier"

turkeytotal — Tue, 22 Jun 2021 04:10:04 +0000

they drop pamphlets in the water, of course

New comment by turkeytotal in "Bill Hwang of Archegos Capital lost $20B in two days"

turkeytotal — Wed, 12 May 2021 19:49:41 +0000

Specific or not (yes many different types of institutions can access these markets), hedge funds are known for taking highly leveraged bets with this overnight cash. There is a huge market for sponsored repo trades.

Hedge funds were most certainly a part of this problem, and were bailed out.

New comment by turkeytotal in "Bill Hwang of Archegos Capital lost $20B in two days"

turkeytotal — Wed, 12 May 2021 17:29:33 +0000

Happens all the time.

e.g. https://www.nytimes.com/2020/07/23/business/economy/hedge-fu...

New comment by turkeytotal in "Show HN: Purchase Virtual Prepaid Cards with Bitcoin via Lightning or Coinbase"

turkeytotal — Tue, 09 Mar 2021 21:41:21 +0000

I am surprised to hear that the NYDFS considers a service that facilitates the sale of cash equivalents for cryptocurrency exempt from licensing. Would you mind sharing more?

New comment by turkeytotal in "Show HN: Purchase Virtual Prepaid Cards with Bitcoin via Lightning or Coinbase"

turkeytotal — Tue, 09 Mar 2021 18:43:12 +0000

Cool product! Can you elaborate on the regulatory framework you guys operate under? I am surprised to see so little data collection for such high volumes (up to $10,000 / day). Do you guys have a BitLicense? Or any MT licenses for the other 49 states?

New comment by turkeytotal in "Ask HN: How to mitigate “SMS layer” DDoS attacks with Twilio-style services?"

turkeytotal — Mon, 11 May 2020 15:14:07 +0000

FWIW, I looked through the APIs and while I did see mechanisms for rejecting phone calls and faxes, I did not see a way to block specific numbers from sending you SMS. Not that it matters, free inbound more or less solves the problem. Thanks again.

New comment by turkeytotal in "Ask HN: How to mitigate “SMS layer” DDoS attacks with Twilio-style services?"

turkeytotal — Mon, 11 May 2020 01:27:56 +0000

>Your carrier should not be charging you for inbound SMS

Agreed!

>look at Teli, Telnyx & Signalwire

Thank you, a quick glance seems to indicate they do not charge for inbound SMS on local numbers.

Ask HN: How to mitigate “SMS layer” DDoS attacks with Twilio-style services?

turkeytotal — Mon, 11 May 2020 01:00:27 +0000

Recently a website that does customer support over SMS was DDOS'd. An angry customer wrote a script to spam the support line with thousands of texts. A hefty bill was racked up, but thankfully the customer was placated and the attack stopped.

It quickly came to the service's attention that Twilio (and any downstream providers) only supports blocking numbers for inbound calls:

https://support.twilio.com/hc/en-us/articles/223181648-Is-there-a-way-to-block-incoming-SMS-on-my-Twilio-phone-number-

The service is in search for an alternative, and hoping a fellow HN-er would be able to provide some insight/mitigations. It appears bandwidth.com does not support blocking SMS from specific numbers either, so the concern is that this may be a limitation of the telephony system.

Thank you in advance :)

Comments URL: https://news.ycombinator.com/item?id=23137845

Points: 2

# Comments: 5

New comment by turkeytotal in "IBM's Summit simulates molecular dynamics to find Covid-19 therapeutics"

turkeytotal — Fri, 20 Mar 2020 02:10:16 +0000

Abstract:

The novel Wuhan coronavirus (SARS-CoV-2) has been sequenced, and the virus shares substantial similarity with SARS-CoV. Here, using a computational model of the spike protein (S-protein) of SARS-CoV-2 interacting with the human ACE2 receptor, we make use of the world's most powerful supercomputer, SUMMIT, to enact an ensemble docking virtual high-throughput screening campaign and identify small-molecules which bind to either the isolated Viral S-protein at its host receptor region or to the S protein-human ACE2 interface. We hypothesize the identified small-molecules may be repurposed to limit viral recognition of host cells and/or disrupt host-virus interactions. A ranked list of compounds is given that can be tested experimentally

Additional snippet:

Here we combine restrained temperature replica-exchangemolecular dynamics (restrained T-REMD) simulations with virtual high-throughput screening in an ensemble docking campaign to identify well-characterized drugs, metabolites, and/or natural products that may disrupt S-protein:ACE2 receptor interface stability or the ability of the S-protein to recognize the ACE2 receptor. From this ensemble docking campaign,we provide a ranking of the predicted binding affinities ofover 8000 drugs, metabolites, and natural products (and their isomers)with regards to the COVID-19 S-protein and the S-protein:ACE2 receptor. Further, we highlight seven of our top ranked compounds, which are currently available and have had either regulatory approval as drugs or have had multiple prior studies which indicating high-potential for therapeuticuse

IBM's Summit simulates molecular dynamics to find Covid-19 therapeutics

turkeytotal — Fri, 20 Mar 2020 02:05:28 +0000

Article URL: https://chemrxiv.org/articles/Repurposing_Therapeutics_for_the_Wuhan_Coronavirus_nCov-2019_Supercomputer-Based_Docking_to_the_Viral_S_Protein_and_Human_ACE2_Interface/11871402/3

Comments URL: https://news.ycombinator.com/item?id=22633854

Points: 3

# Comments: 1

New comment by turkeytotal in "PayPal stops payouts to models on Pornhub"

turkeytotal — Fri, 15 Nov 2019 01:12:11 +0000

What sort of censorship are you referring to? If taproot-schnorr is deployed and adopted, cooperative channel operations will look exactly like normal single-sig transactions. As for routing censorship, if one node fails to route for me, I can open a channel with a different node and route around them.

New comment by turkeytotal in "Ongoing Google Cloud Incident – Sep 24 2019"

turkeytotal — Wed, 25 Sep 2019 01:03:12 +0000

Was unable to redeploy one of our cloud functions for quite awhile there.

New comment by turkeytotal in "Telegram moves to protect identity of Hong Kong protesters"

turkeytotal — Sat, 31 Aug 2019 02:47:47 +0000

VOIP numbers are much more anon-accessible. You can buy a ready to go google account with voice enabled if you know where to look.

New comment by turkeytotal in "Hacking My Mother’s Phone to Save Her Memories"

turkeytotal — Tue, 11 Jun 2019 18:01:09 +0000

This story is another testament to the dangers of using SMS as second factor.

New comment by turkeytotal in "Google Deprecates “Sort by Date” Search Function"

turkeytotal — Sat, 27 Apr 2019 20:15:55 +0000

Even if Google's dates are not "high confidence," this function was still useful outside of News search. Very disappointed to see this be retired.

Google Deprecates “Sort by Date” Search Function

turkeytotal — Sat, 27 Apr 2019 20:13:27 +0000

Article URL: https://twitter.com/searchliaison/status/1115706765088182272

Comments URL: https://news.ycombinator.com/item?id=19767380

Points: 4

# Comments: 2

New comment by turkeytotal in "WhatsApp co-founder accuses Facebook of trading privacy for revenue"

turkeytotal — Sat, 16 Mar 2019 07:21:20 +0000

Brian has done that with Signal Foundation:

https://signal.org/blog/signal-foundation/