Hacker News: tusimi

New comment by tusimi in "Claude Fable 5.1 and Claude Mythos 5.1"

tusimi — Tue, 01 Sep 2026 18:49:55 +0000

aaaaand its blocked from doing even basic tasks in biotech...

New comment by tusimi in "We don't search databases–we calculate reality. EXXOGEN is now live"

tusimi — Mon, 17 Aug 2026 17:02:11 +0000

We have DESRES at home

New comment by tusimi in "Aspirin reverses diet-driven depression-like behavior"

tusimi — Wed, 29 Jul 2026 13:49:31 +0000

all the time. lack of appropriate/translatable preclinical models is one of the largest barriers to new meds. in practice, if you can't find a mouse that has the same disease its almost impossible to prove your cure works,, even if it would in humans

New comment by tusimi in "The Isomorphic Labs Drug Design Engine unlocks a new frontier beyond AlphaFold"

tusimi — Sat, 18 Jul 2026 03:07:55 +0000

"In November 2024, preliminary results of CASP16 showed AlphaFold 3-based models did not significantly outperform older methods for predicting protein-ligand interactions. The top performing models in the CASP16 Pose Prediction for Pharma Targets section were ClusPro[13] and CoDock[14] utilizing AlphaFold 2 based predictions, human visual inspection, and manual adjustments.[15]

In April 2025 Isomorphic Labs raised $600 Million in its first ever external funding round, led by Thrive Capital.[16][17]"

https://en.wikipedia.org/wiki/Isomorphic_Labs

New comment by tusimi in "Tesla is recalling its cheaper Cybertruck because the wheels might fall off"

tusimi — Fri, 08 May 2026 14:22:26 +0000

"All 173 of the RWD Cybertrucks sold by Tesla are being recalled"

173...

New comment by tusimi in "Zed 1.0"

tusimi — Fri, 01 May 2026 14:05:24 +0000

This is not an official Notepad++ release. It’s an unauthorized project misusing the Notepad++ trademark.

https://notepad-plus-plus.org/news/npp-trademark-infringemen...