<rss version="2.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Hacker News: ultimape</title><link>https://news.ycombinator.com/user?id=ultimape</link><description>Hacker News RSS</description><docs>https://hnrss.org/</docs><generator>hnrss v2.1.1</generator><lastBuildDate>Mon, 27 Apr 2026 18:09:10 +0000</lastBuildDate><atom:link href="https://hnrss.org/user?id=ultimape" rel="self" type="application/rss+xml"></atom:link><item><title><![CDATA[New comment by ultimape in "Why public chats are better than direct messages"]]></title><description><![CDATA[
<p>Good luck with all the alcoholic types you're going to be generating as a side effect of forcing people with anxiety issues into talking in a public space. You'll be seeing self-medication for gaba dysfunctions as people try to keep their job.
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303399/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303399/</a></p>
]]></description><pubDate>Fri, 09 Sep 2022 17:05:06 +0000</pubDate><link>https://news.ycombinator.com/item?id=32781929</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=32781929</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=32781929</guid></item><item><title><![CDATA[New comment by ultimape in "Togethr: Own Mastodon-compatible decentralized social network instance"]]></title><description><![CDATA[
<p>This appears to be a managed hosting provider offering access to a pleroma instance underneath, not a software package.</p>
]]></description><pubDate>Thu, 05 May 2022 15:10:40 +0000</pubDate><link>https://news.ycombinator.com/item?id=31274360</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=31274360</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=31274360</guid></item><item><title><![CDATA[New comment by ultimape in "COBOL Programming Course"]]></title><description><![CDATA[
<p>LEARNING COBOL IS VERY GOOD IF YOU WANNA INFILTRATE AND HACK LEGACY SYSTEMS.</p>
]]></description><pubDate>Sun, 01 May 2022 18:55:11 +0000</pubDate><link>https://news.ycombinator.com/item?id=31227632</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=31227632</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=31227632</guid></item><item><title><![CDATA[New comment by ultimape in "YouTuber builds his own x-ray machine after $69k hospital bill (2021)"]]></title><description><![CDATA[
<p>In the context of buying used hospital equipment and the concerns of a layman making a mistake due to the very confusion you highlight... Seems at least relevant.</p>
]]></description><pubDate>Thu, 24 Mar 2022 16:02:06 +0000</pubDate><link>https://news.ycombinator.com/item?id=30791739</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=30791739</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=30791739</guid></item><item><title><![CDATA[New comment by ultimape in "Electric fields, not individual neurons, may hold information in memory: study"]]></title><description><![CDATA[
<p>Maybe. There was a guy who induced aphantasia after a stem cell transplant and one of the hypothesis is the loss of gut bacteria via antibiotics.
<a href="https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8143657/" rel="nofollow">https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8143657/</a><p>I reversed a life-long case of Prosopagnosia after doing some n-of-1 experiments with replenishing my gut bacteria, so it seems plausible to me that losing intestines could impact this.<p>I also have a friend had her intestines removed due to Crohn's disease. She had an infection from the surgery that put her in a coma she woke up unable to picture things in her head. Hard to say what caused it.</p>
]]></description><pubDate>Mon, 14 Mar 2022 05:48:40 +0000</pubDate><link>https://news.ycombinator.com/item?id=30668929</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=30668929</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=30668929</guid></item><item><title><![CDATA[New comment by ultimape in "IBM open sources fully-functional Lego microscope design (2020)"]]></title><description><![CDATA[
<p>Many of the plastics have stress lines that show up under polarized lens IIRC. And many of the techniques used to detect crystals in fluids also use polarized light that would be incompatible with such a lens.</p>
]]></description><pubDate>Mon, 07 Mar 2022 01:37:38 +0000</pubDate><link>https://news.ycombinator.com/item?id=30583219</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=30583219</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=30583219</guid></item><item><title><![CDATA[New comment by ultimape in "PUBG Game maker says Apple, Google selling rip-offs in new lawsuit"]]></title><description><![CDATA[
<p>Pubg itself is a ripoff of minecraft hunger games.</p>
]]></description><pubDate>Thu, 13 Jan 2022 03:43:39 +0000</pubDate><link>https://news.ycombinator.com/item?id=29916593</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=29916593</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=29916593</guid></item><item><title><![CDATA[New comment by ultimape in "Making Open Source economy more viable with dual license collectives"]]></title><description><![CDATA[
<p>Next level game theory: going with AGPL specifically because google banned it lmao.</p>
]]></description><pubDate>Mon, 10 Jan 2022 09:51:25 +0000</pubDate><link>https://news.ycombinator.com/item?id=29872489</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=29872489</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=29872489</guid></item><item><title><![CDATA[New comment by ultimape in "Hundreds of ancient Maya sites hidden under Mexico reveal a mysterious blueprint"]]></title><description><![CDATA[
<p>I found a bunch of churches were built on ground that has been shown to contain soil bacteria with anti-biofilm properties. This means the 'holy ground' was literally able to heal wounds. Likewise, a lot of 'holy water' has similar healing properties because it often contained gold and silver nanoparticles.<p>The ritual use of these sites usually occurred afterwards once economic situation and custom solidified it as an area of rulership. Often cargo-cult'ing what would have been a genuine healing process.</p>
]]></description><pubDate>Sun, 07 Nov 2021 16:39:46 +0000</pubDate><link>https://news.ycombinator.com/item?id=29140934</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=29140934</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=29140934</guid></item><item><title><![CDATA[New comment by ultimape in "Car accidents cause death, injury and trauma. Why do we shrug them off?"]]></title><description><![CDATA[
<p>Obesity is a risk factor for many types of cancer and also risk for Alzheimer's because both are tied to the hip with blood sugar problems.<p>Most of the older folks to who get cancer and age related neurodegenerative disease also seem to succumb to age related diabetes symptoms and poor insulin.<p>These things aren't separate-able as cleanly as you suggest.</p>
]]></description><pubDate>Tue, 26 Oct 2021 00:25:18 +0000</pubDate><link>https://news.ycombinator.com/item?id=28995002</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=28995002</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=28995002</guid></item><item><title><![CDATA[New comment by ultimape in "Car accidents cause death, injury and trauma. Why do we shrug them off?"]]></title><description><![CDATA[
<p>What if you don't see them because its the middle of the night and they're not at a crosswalk, a situation designed to have high visibility?</p>
]]></description><pubDate>Tue, 26 Oct 2021 00:20:40 +0000</pubDate><link>https://news.ycombinator.com/item?id=28994972</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=28994972</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=28994972</guid></item><item><title><![CDATA[New comment by ultimape in "Deadly infection linked to contaminated room spray sold at Walmart"]]></title><description><![CDATA[
<p>It largely gets captured in the mucus barrier in the lungs, but people with COPD or asthma also tend to have poor barrier function (Both mucus and lung liner) so it leaks into the blood stream easier.</p>
]]></description><pubDate>Tue, 26 Oct 2021 00:10:34 +0000</pubDate><link>https://news.ycombinator.com/item?id=28994896</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=28994896</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=28994896</guid></item><item><title><![CDATA[New comment by ultimape in "The 100 MHz 6502"]]></title><description><![CDATA[
<p>Unconventional computing platforms FTW. <a href="https://phys.org/news/2012-04-scientists-crab-powered.html" rel="nofollow">https://phys.org/news/2012-04-scientists-crab-powered.html</a></p>
]]></description><pubDate>Thu, 14 Oct 2021 22:02:08 +0000</pubDate><link>https://news.ycombinator.com/item?id=28870775</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=28870775</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=28870775</guid></item><item><title><![CDATA[New comment by ultimape in "This implanted microchip may one day control your sleep"]]></title><description><![CDATA[
<p>Have you managed to boost oxidative stress removal? <a href="https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4117056/" rel="nofollow">https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4117056/</a></p>
]]></description><pubDate>Tue, 21 Sep 2021 00:51:29 +0000</pubDate><link>https://news.ycombinator.com/item?id=28600868</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=28600868</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=28600868</guid></item><item><title><![CDATA[New comment by ultimape in "Drug users use a lot of drugs"]]></title><description><![CDATA[
<p>Survival stress also impacts liver function leading to poor lipid metabolism which in turn can impact cholesterol absorption and lead to cortical thinning. Which is also an effect that we see from methamphetamine use in various animal models, which by it's nature of being controlled trail seems to exclude the stress factor.
<a href="https://pubmed.ncbi.nlm.nih.gov/28689763/" rel="nofollow">https://pubmed.ncbi.nlm.nih.gov/28689763/</a><p>I would agree with you in general, but there are situations where prescribed methamphetamines also lead to cortical thinning when not used as recreationally. This seems to suggest that stress may not be the entire player here <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870784/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870784/</a><p>It was likely decided because of the dose of meth found in the persons systems that correlates with various findings on dose-dependence <a href="https://jamanetwork.com/journals/jamapsychiatry/fullarticle/1555603" rel="nofollow">https://jamanetwork.com/journals/jamapsychiatry/fullarticle/...</a><p>If you would like to read more about PTSD findings as it relates to stress and liver function, I would be happy to expound upon the way that corticosteroids impact gut bacteria that directly affect FXR metabolism and bile acids and further lead to cortical thinning. <a href="https://academic.oup.com/cercor/article/30/2/575/5521088" rel="nofollow">https://academic.oup.com/cercor/article/30/2/575/5521088</a><p>Its really fascinating how a drug like methamphetamine impact neuroactive steroids that impact the same pathways tha stress does. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862925/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862925/</a> We've been able to reverse it in rats <a href="https://www.sciencedaily.com/releases/2013/10/131007093739.htm" rel="nofollow">https://www.sciencedaily.com/releases/2013/10/131007093739.h...</a></p>
]]></description><pubDate>Fri, 18 Jun 2021 04:31:53 +0000</pubDate><link>https://news.ycombinator.com/item?id=27547379</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=27547379</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=27547379</guid></item><item><title><![CDATA[New comment by ultimape in "Don't just shorten your URL, make it suspicious and frightening (2010)"]]></title><description><![CDATA[
<p>Ironically the supicious and fightening url generator thinks that isn't a valid url. Tho it does seem to work in reverse <a href="https://aaa.aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa.com/a?áaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂáaaÂåAæãæãæaâÁáÆáÆææææææáÅæâåAåàåãæÀæäæáåÃáÅåâåÆåÄáÆåâæáåäåàæãåäáÅæaåAæa" rel="nofollow">https://aaa.aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa...</a></p>
]]></description><pubDate>Wed, 16 Jun 2021 02:34:53 +0000</pubDate><link>https://news.ycombinator.com/item?id=27524248</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=27524248</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=27524248</guid></item><item><title><![CDATA[New comment by ultimape in "Why bugs might feel “impossible”"]]></title><description><![CDATA[
<p>I routed out a couple thousand heisenbugs in an old system I was working on. Turned out the web based platform had no cache invalidation / cache-busting feature enabled, so any time an update would be published, the browsers didn't always get the changes.<p>The icing on the cake was that it was our app that was bad, and the 'fix' they implemented was a completely broken work-around.<p>It was SOP to instruct the clients to turn off browser caching. So the app was slow as well. Inevitably the Client's on-site IT would install a new desktop and forget to turn off browser caching. So you'd get these weird states were errors would occur randomly and depend entirely on if someone had changed or hadn't set that setting.<p>Years of cruft and chaotic deployment workflow meant there were easily 10,000 different places where the cache busting would need to be implemented. I figured out a way to fix this using nginx as a caching layer, and using features of a brand name Web Toolkit which we had already partly implemented without caching. Even had a test harness set up and way to catch bugs during a transitionary stage.<p>Shame there wasn't any specific tickets on this exact fix because otherwise I would still be working there. Sure, I was assigned a bunch of the random error ones and found out what was causing them, but apparently being assigned a ticket and fixing the problem isn't part of my job?!<p>The head of the web dev team (and my manager) quit shortly after I was hired. I now understand why.<p>Fixing bugs is impossible sometimes.</p>
]]></description><pubDate>Tue, 15 Jun 2021 15:57:07 +0000</pubDate><link>https://news.ycombinator.com/item?id=27517324</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=27517324</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=27517324</guid></item><item><title><![CDATA[New comment by ultimape in "Sperm DNA methylation epimutation biomarker for paternal offspring autism"]]></title><description><![CDATA[
<p>I haven't found one specifically on autism. Most of the mothers' risk in offspring seems to be gestational factors during brain development stages, and later on impacts on milk.<p>This gets close
"Epigenetics in Families: Covariance between Mother and Child Methylation Patterns" <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913850/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913850/</a></p>
]]></description><pubDate>Sat, 12 Jun 2021 00:35:53 +0000</pubDate><link>https://news.ycombinator.com/item?id=27480199</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=27480199</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=27480199</guid></item><item><title><![CDATA[New comment by ultimape in "Fractalrabbit: Simulate realistic trajectory data from sporadic reporting"]]></title><description><![CDATA[
<p>The companion git repo is fascinating.
<a href="https://github.com/probabilist-us/contact-rabbit" rel="nofollow">https://github.com/probabilist-us/contact-rabbit</a><p>Trying to reverse engineer indirect infection.<p>This is useful for seeding propaganda and any other virally driven phenomena by modeling gathered exploratory behavior of a user.</p>
]]></description><pubDate>Fri, 11 Jun 2021 20:47:51 +0000</pubDate><link>https://news.ycombinator.com/item?id=27478274</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=27478274</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=27478274</guid></item><item><title><![CDATA[New comment by ultimape in "A robot to replace the need for farmers to go inside the grain bin"]]></title><description><![CDATA[
<p>Yes, this is basically a mini "screw-propelled vehicle"</p>
]]></description><pubDate>Fri, 11 Jun 2021 00:01:19 +0000</pubDate><link>https://news.ycombinator.com/item?id=27467669</link><dc:creator>ultimape</dc:creator><comments>https://news.ycombinator.com/item?id=27467669</comments><guid isPermaLink="false">https://news.ycombinator.com/item?id=27467669</guid></item></channel></rss>