Hacker News: vaelin

New comment by vaelin in "Project Glasswing: Securing critical software for the AI era"

vaelin — Wed, 08 Apr 2026 16:04:06 +0000

It's models all the way down.

New comment by vaelin in "A protein that disrupts cells’ energy centers may be a culprit in CFS/ME"

vaelin — Tue, 22 Aug 2023 15:57:37 +0000

It's possibly the same thing. Endoplasmic Reticulum Stress, the type of stress which may cause this protein to become elevated, was induced in mice by exposing them to endotoxin, a type of toxin produced in the gut.

So gut dysbiosis may trigger this very mechanism.

New comment by vaelin in "MacBook Pro 16" 2019 Teardown"

vaelin — Tue, 19 Nov 2019 08:20:22 +0000

Is the screen noticeably larger than the 15 inch? I am thinking of buying one but can't get to a store to see it for myself.

The Blockchain Solution to Our Deepfake Problems

vaelin — Fri, 31 May 2019 14:45:03 +0000

Article URL: https://www.wired.com/story/the-blockchain-solution-to-our-deepfake-problems/

Comments URL: https://news.ycombinator.com/item?id=20061342

Points: 7

# Comments: 4

New comment by vaelin in "Biomarker for chronic fatigue syndrome identified"

vaelin — Sun, 05 May 2019 16:20:57 +0000

It could also be measuring the result of extreme inactivity. I am bedridden, and I have no doubt that lying in bed for years has had a profound effect on my physiology independently of my ME/CFS.

The acid test will be when we compare ME/CFS patients to matched MS patients. However, as Ron Davis has stated, it might also be the case that MS patients have ME/CFS, as ME/CFS is highly heterogenous and may be arrived at from multiple directions.

There are lots of details that need to be ironed out. Nevertheless, this is exciting news.

New comment by vaelin in "Biomarker for chronic fatigue syndrome identified"

vaelin — Sun, 05 May 2019 16:15:39 +0000

Not in the paper, but Ron gave a talk where he mentioned an MS drug (I have forgotten which) and a new drug that targets mitochondria which is not yet licensed for anything.

Sorry I can't be more specific. I don't remember the details.

New comment by vaelin in "Biomarker for chronic fatigue syndrome identified"

vaelin — Sun, 05 May 2019 16:10:57 +0000

I have ME/CFS. The evidence has been clear that it is a physical condition for quite a while now. In fact, the Institute of Medicine clarified that point in a thorough report in 2015:

> The primary message of the committee’s report is that ME/CFS is a serious, chronic, complex, systemic disease that often can profoundly affect the lives of patients.

>Many health care providers are skeptical about the seriousness of ME/CFS, mistake it for a mental health condition, or consider it a figment of the patient’s imagination. Misconceptions or dismissive attitudes on the part of health care providers make the path to diagnosis long and frustrating for many patients. The committee stresses that health care providers should acknowledge ME/CFS as a serious illness that requires timely diagnosis and appropriate care. [1]

Having said that, I am obviously delighted by this study for a whole host of reasons. A diagnostic test will be hugely beneficial in driving home the message that it is not, in fact, an imaginary condition. It will also be beneficial in testing treatment outcomes, as the lack of a test has made gauging treatment efficacy very challenging.

There are a lot of hurdles to overcome yet, but we are FINALLY on the right path.

[1] Quotes contained in the Key Brief PDF - http://www.nationalacademies.org/hmd/Reports/2015/ME-CFS.asp...