Hacker News: vapemaster

New comment by vapemaster in "Microscale Thermite Reaction"

vapemaster — Sat, 16 May 2026 00:33:04 +0000

wow I hadn't heard of this but it's quite cool. aka Nano-Thermite

https://en.wikipedia.org/wiki/Nano-thermite

Gmail / Google Workspace Incendent Underway

vapemaster — Wed, 08 Apr 2026 18:47:59 +0000

Article URL: https://www.google.com/appsstatus/dashboard/incidents/224ozRqzW4sFBDK8hLnT

Comments URL: https://news.ycombinator.com/item?id=47694520

Points: 8

# Comments: 2

Sonnet 5 (Full Text)

vapemaster — Tue, 03 Feb 2026 17:39:23 +0000

Article URL: https://www.folger.edu/explore/shakespeares-works/shakespeares-sonnets/read/5/

Comments URL: https://news.ycombinator.com/item?id=46874206

Points: 12

# Comments: 1

New comment by vapemaster in "Verizon Is Down"

vapemaster — Thu, 15 Jan 2026 01:21:34 +0000

Thought I was going insane today.

Verizon Is Down

vapemaster — Thu, 15 Jan 2026 01:21:34 +0000

Article URL: https://www.macrumors.com/2026/01/14/verizon-is-down-iphone-sos/

Comments URL: https://news.ycombinator.com/item?id=46626652

Points: 7

# Comments: 4

New comment by vapemaster in "Collaboration sucks"

vapemaster — Tue, 11 Nov 2025 21:53:06 +0000

You guys need to work on harder problems.

Claude Opus refuses to answer biotech questions

vapemaster — Thu, 21 Aug 2025 16:51:14 +0000

Claude Opus has started refusing to answer any moderately detailed question regarding biotech / drug discovery related tasks. Sonnet will still answer but at it's usual level of inaccuracy and vagueness that makes it unhelpful. Why would this pose a safety concern? What am I missing.

ie prompt: I have a small molecule I want to optimize oral bioavailability for in cynos and humans, what is the best formulation including novel excipients and permeation enhancers to achieve this?

Response: Claude is unable to respond to this request, which appears to violate our Usage Policy. Please start a new chat.

Comments URL: https://news.ycombinator.com/item?id=44975032

Points: 2

# Comments: 0

X is blocking links to Signal

vapemaster — Tue, 18 Feb 2025 17:18:53 +0000

Article URL: https://www.theverge.com/news/613997/x-blocks-signal-me-links-errors

Comments URL: https://news.ycombinator.com/item?id=43092336

Points: 4

# Comments: 1

New comment by vapemaster in "Ask HN: Weirdest Computer Architecture?"

vapemaster — Thu, 01 Aug 2024 19:45:01 +0000

since this is a bit of a catch-all thread, i'll toss Anton into the ring: a whole bunch of custom ASICs to do Molecular Dynamics simulations from D.E. Shaw Research

https://en.wikipedia.org/wiki/Anton_(computer)

New comment by vapemaster in "Leap – Chemistry Through a Computational Lens"

vapemaster — Mon, 15 Jul 2024 22:45:14 +0000

not hating on the great amber - but why LEaP on the front page of HN with no context...?

happy to see some light shown on the grim state of comp chem file formats and their shockingly lossy interconversion but I'm not sure that was the OP's intent?

Hot Take: Prompt engineering isn't engineering. It's discovery

vapemaster — Fri, 26 Jan 2024 18:38:43 +0000

I'm in the drug discovery space, and for all the "engineering biology" talk that's around these days, I find a bunch of parallels to drug discovery in the AI, particularly LLM space.

The fact that these models get created and the poked and prodded with prompts reminds me a ton of chemical biology, aka the field of using chemicals to investigate biology.

It would appear that in the case of AI, the engineering has become art.

Ironically these technologies are the ones being heralded as the way to take biology and turn it into an engineering problem.

I always come back to may favorite XKCD "Here to Help" https://xkcd.com/1831

Comments URL: https://news.ycombinator.com/item?id=39146209

Points: 2

# Comments: 2

How deep is the brain? The shallow brain hypothesis

vapemaster — Mon, 30 Oct 2023 00:28:38 +0000

Article URL: https://www.nature.com/articles/s41583-023-00756-z

Comments URL: https://news.ycombinator.com/item?id=38064287

Points: 202

# Comments: 178

New comment by vapemaster in "Ask HN: Why does Apple refuse to add window snapping to macOS?"

vapemaster — Tue, 20 Jun 2023 05:01:18 +0000

long time windows user that switched to mac due to Apple Silicon dominance on the laptop experience.

This, 1000x this.

It's utterly bizarre that the window management paradigm is "let 'em all stack up and make it easy to spread 'em all out"

At first I thought I didn't get the paradigm. Now I get that I don't get the idea behind the paradigm.

Rectangle (pro version) fixes some of this and adds some really cool features. And because of the Apple app hegemony, it does work nearly OS level good. But why, oh why does this have to be 3rd party?

It's like some any UX pattern baked in since Lisa?

Griptape – a modular Python framework for LLM workflows, tools, memory, and data

vapemaster — Thu, 20 Apr 2023 16:55:06 +0000

Article URL: https://github.com/griptape-ai/griptape

Comments URL: https://news.ycombinator.com/item?id=35642820

Points: 4

# Comments: 0

New comment by vapemaster in "Zrok: Open-source peer to peer"

vapemaster — Wed, 08 Feb 2023 22:43:54 +0000

this was an awesome, non-snarky, explanatory comment. thanks for this.

New comment by vapemaster in "Mac's command key is worse than Window's ctrl"

vapemaster — Tue, 31 Jan 2023 01:53:55 +0000

touché

New comment by vapemaster in "Mac's command key is worse than Window's ctrl"

vapemaster — Mon, 30 Jan 2023 15:28:56 +0000

except that you still use command to copy and paste in the terminal

New comment by vapemaster in "Mac's command key is worse than Window's ctrl"

vapemaster — Mon, 30 Jan 2023 15:28:00 +0000

agreed, the fold under makes me use the side of my thumb on command which is much less natural or tactile than stretching my pinky to use the pad.

New comment by vapemaster in "Mac's command key is worse than Window's ctrl"

vapemaster — Mon, 30 Jan 2023 15:23:52 +0000

I immediately had to get Karibiner to at least give me my home and end keys back on a external keyboard.

I've been to aggressively remapping that I don't then create a similar problem when using another machine I don't own but maybe I'll give in and go the more custom route

New comment by vapemaster in "Mac's command key is worse than Window's ctrl"

vapemaster — Mon, 30 Jan 2023 15:21:02 +0000

well [ctrl] + are used for window management by default