Hacker News: wordglyph

New comment by wordglyph in "Show HN: I built a dual crossword puzzle where two crosswords share one grid"

wordglyph — Fri, 01 May 2026 16:46:25 +0000

Nice job! I just recently coded my word game into an app of your on desktop you can still play it. Wordglyph.xyz

New comment by wordglyph in "Show HN: Email for AI Agents"

wordglyph — Fri, 01 May 2026 16:41:42 +0000

are your mail servers whitelisted with the big players.

New comment by wordglyph in "Show HN: s@: decentralized social networking over static sites"

wordglyph — Thu, 12 Mar 2026 04:22:03 +0000

have you considered Replace X25519 with a post quantum cryptography key encapsulation mechanism like kyber or saber?

New comment by wordglyph in "Show HN: I built a sub-500ms latency voice agent from scratch"

wordglyph — Tue, 03 Mar 2026 17:36:42 +0000

What do you think about https://app.sesame.com/

New comment by wordglyph in "I pitched a roller coaster to Disneyland at age 10 in 1978"

wordglyph — Tue, 24 Feb 2026 22:27:52 +0000

Good insight. Yes, I do remember at the time, purposely thinking I must lead with my age knowing instinctively that somehow that would help me and they would be more likely to pay attention.

New comment by wordglyph in "Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows"

wordglyph — Tue, 24 Feb 2026 20:44:20 +0000

You do realize they already are investigating, right? Even looking into MS and parkinson. ALZHEIMER’S DISEASE (AD) and AD DEMENTIA Umbrella review (systematic reviews of SRs): https://www.nature.com/articles/s44400-025-00048-6

Systematic review + meta-analysis (basal microbiota; AD): https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002... https://pmc.ncbi.nlm.nih.gov/articles/PMC11672027/

Replicated case-control + functional metagenomics (AD dementia): https://alz-journals.onlinelibrary.wiley.com/doi/full/10.100...

Large-cohort metagenomics (stage-specific / early pathology signals): https://pubmed.ncbi.nlm.nih.gov/40164697

Mendelian randomization (AD): https://pubmed.ncbi.nlm.nih.gov/38788075/ https://www.sciencedirect.com/science/article/pii/S227458072... https://pubmed.ncbi.nlm.nih.gov/40665707/ https://journals.sagepub.com/doi/10.1177/25424823261422629 https://www.medrxiv.org/content/10.1101/2025.08.20.25333769v...

Narrative / mechanisms (useful synthesis, not primary causal proof): https://www.sciencedirect.com/science/article/abs/pii/S15681...

MILD COGNITIVE IMPAIRMENT (MCI) / DEMENTIA (cognition-focused evidence) Systematic review (MCI or Alzheimer’s dementia; PRISMA, PROSPERO): https://www.mdpi.com/2035-8377/17/10/155 https://pubmed.ncbi.nlm.nih.gov/41149776/

Scoping review (MCI and AD gut microbiomes + interventions, through Feb 2023): https://pmc.ncbi.nlm.nih.gov/articles/PMC12825029/

Systematic review of microbiota-targeted interventions for cognition/dementia risk: https://www.sciencedirect.com/science/article/pii/S027153172...

RCT-focused systematic review/meta-analysis of probiotics for cognitive impairment risk/AD/MCI: https://pmc.ncbi.nlm.nih.gov/articles/PMC12645680/

FMT in dementia/MCI context (review of effects across neuro cohorts): https://www.sciencedirect.com/science/article/pii/S266635462...

MULTIPLE SCLEROSIS (MS) Microbiome signatures via global data integration / ML: https://pmc.ncbi.nlm.nih.gov/articles/PMC12383397/

Systematic review/meta-analysis of probiotics in MS (preclinical + clinical): https://journals.plos.org/plosone/article?id=10.1371/journal...

Systematic review + meta-analysis (antimicrobial exposure and MS risk; microbiome-disruption relevant): https://www.sciencedirect.com/science/article/abs/pii/S22110...

Mendelian randomization (gut microbiota causally linked to MS): https://pubmed.ncbi.nlm.nih.gov/39065244/ https://www.mdpi.com/2076-2607/12/7/1476

Broad MS gut dysbiosis and therapeutic modulation review: https://pmc.ncbi.nlm.nih.gov/articles/PMC12668904/

MS gut-brain-barrier and intestinal barrier review: https://www.frontiersin.org/journals/immunology/articles/10....

Example MS cohort biomarker/signature work: https://www.nature.com/articles/s41598-024-64369-x https://www.nature.com/articles/s41598-025-19998-1

PARKINSON’S DISEASE (PD) Multi-cohort metagenomic meta-analysis (Nat Commun, 2025): https://www.nature.com/articles/s41467-025-56829-3 https://pubmed.ncbi.nlm.nih.gov/40335465/

Large metagenomics cohort (Nat Commun, 2022): https://www.nature.com/articles/s41467-022-34667-x

Integrated multi-cohort gut metagenome (Movement Disorders, 2023): https://pubmed.ncbi.nlm.nih.gov/36691982/ https://movementdisorders.onlinelibrary.wiley.com/doi/10.100...

Metagenomic analysis (Movement Disorders, 2024): https://pubmed.ncbi.nlm.nih.gov/39192744/

PD causal-inference and MR discussion (review-type synthesis): https://pmc.ncbi.nlm.nih.gov/articles/PMC12512240/

MR study example (PD gut microbiota): https://journals.lww.com/md-journal/fulltext/2025/10310/caus...

New comment by wordglyph in "Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows"

wordglyph — Tue, 24 Feb 2026 17:13:05 +0000

Your gut bacteria is the prevention and the cure.

New comment by wordglyph in "I pitched a roller coaster to Disneyland at age 10 in 1978"

wordglyph — Tue, 24 Feb 2026 17:08:25 +0000

He sent the letter in April 1979! He was only 3 months into the job.

New comment by wordglyph in "I pitched a roller coaster to Disneyland at age 10 in 1978"

wordglyph — Tue, 24 Feb 2026 17:05:38 +0000

Note to self. Build time machine and fix this.

New comment by wordglyph in "I pitched a roller coaster to Disneyland at age 10 in 1978"

wordglyph — Tue, 24 Feb 2026 15:36:43 +0000

That's amazing!

I pitched a roller coaster to Disneyland at age 10 in 1978

wordglyph — Tue, 24 Feb 2026 13:03:51 +0000

Article URL: https://wordglyph.xyz/one-piece-at-a-time

Comments URL: https://news.ycombinator.com/item?id=47136604

Points: 561

# Comments: 200

New comment by wordglyph in "Show HN: I Made Something Weird"

wordglyph — Fri, 30 Jan 2026 16:06:09 +0000

Is any content generated by ai?

New comment by wordglyph in "Show HN: I've been using AI to analyze every supplement on the market"

wordglyph — Thu, 22 Jan 2026 17:42:05 +0000

This is fantastic! I've been doing this manually for years. My main focus is always what does the research show about xyz supplement on gut bacteria.

New comment by wordglyph in "Show HN: AI background remover that runs 100% in the browser"

wordglyph — Tue, 13 Jan 2026 22:50:03 +0000

Removal worked well but it always downloads a white background no matter if I chose transparent

New comment by wordglyph in "Show HN: PDFClear – Browser-based PDF tools with local AI (WASM+Transformers.js)"

wordglyph — Mon, 24 Nov 2025 20:15:19 +0000

Integrating AI browser stuff is very cool!

New comment by wordglyph in "Show HN: My Light & Spirit – A Clever Indie Puzzle Where Light Becomes Your Tool"

wordglyph — Thu, 20 Nov 2025 17:38:48 +0000

Are you planing to make a web version for mobile?

New comment by wordglyph in "Show HN: 3D Rubik's Cube Speed Cubing in the Browser"

wordglyph — Tue, 11 Nov 2025 12:17:44 +0000

It be fun it you could swipe the rows in the direction you want on mobile

New comment by wordglyph in "Show HN: I built a puzzle game that combines 3 Tiles and Block Puzzle"

wordglyph — Tue, 11 Nov 2025 12:14:41 +0000

Fun! How do you turn off the sound? And you like challenging word games then check out my game https://wordGlyph.xyz

New comment by wordglyph in "Show HN: Built a chess Agent to analyze your games and visualize tactics"

wordglyph — Sun, 02 Nov 2025 11:21:32 +0000

It requires email and payment info to get free trial.

New comment by wordglyph in "Show HN: I built a free VPN that runs directly in Chrome"

wordglyph — Sun, 02 Nov 2025 11:14:37 +0000

Is this running thru your own servers you control? What country are they based in? What is the pricing after 15min? And what methods of payments do you accept?