Hacker News: yosame

New comment by yosame in "UK Biobank health data keeps ending up on GitHub"

yosame — Fri, 24 Apr 2026 00:26:19 +0000

In my experience with health data, the dates are usually offset by a random but constant amount for each person (e.g. id 12345 will have all their dates shifted by +5 weeks) to avoid identification by dates.

Unfortunately the sequence of treatments and locations are usually enough to identify someone, especially if it's a rarer condition.

New comment by yosame in "The future of everything is lies, I guess: Where do we go from here?"

yosame — Thu, 16 Apr 2026 23:35:32 +0000

Not really, you still have to validate the structures it estimates, which minimises any speed gains.

It can help a little bit in the early stages of drug design, but even if it was perfect (which it's not), there's a massive gap between understanding a protein structure, and understanding how a drug will or system will interact with it.

In a broader sense, understanding the structure of a protein is only a small part of drug development. Unfortunately biology is complicated, and we're an extremely far way away from solving it.

New comment by yosame in "Study finds no evidence cannabis helps anxiety, depression, or PTSD"

yosame — Sun, 22 Mar 2026 03:11:08 +0000

I mean the difference is that you just take one in the morning? Which makes adherence easier, makes sure that the delay is constant rather than variable, and reduces abuse liability.

(As an aside, there are more complex extended release mechanisms than just delayed bead release - like lisfexamfetamine is a inactive prodrug, so cleaving the lysine off the amphetamine is rate limited. This has the effect of extended the duration of effect, and reduces the potential to abuse by snorting/iv/etc).

New comment by yosame in "Australia begins enforcing world-first teen social media ban"

yosame — Wed, 10 Dec 2025 22:34:30 +0000

I'm pretty sure this take is incorrect on multiple accounts. Trans demographics tend to skew towards trans women by about a third, not trans men - at least in all the research I've come across.

And regardless, increased acceptance and awareness of different gender identities can very plausibily explain increased numbers, not "social contagion". Calling it a contagion is pretty indicative of your underlying beliefs here.

New comment by yosame in "Uncle Sam wants to scan your iris and collect your DNA, citizen or not"

yosame — Wed, 05 Nov 2025 00:52:33 +0000

Hilariously, this is the second Sam that wants to collect everyones iris's for nefarious purposes

New comment by yosame in "How OpenAI uses complex and circular deals to fuel its multibillion-dollar rise"

yosame — Sat, 01 Nov 2025 01:28:16 +0000

Why would ChatGPT replace google search when search also has AI? At best they'd steal some of Google's market share, which I'd imagine would decline with embedded ads.

New comment by yosame in "Samsung makes ads on smart fridges official with upcoming software update"

yosame — Wed, 29 Oct 2025 00:24:52 +0000

Could you share a guide for how you did this? I've got a TCL TV, and it's constantly frustrating how it shows laggy ads.

New comment by yosame in "Cannabis use associated with quadrupled risk of developing type 2 diabetes"

yosame — Sun, 14 Sep 2025 23:05:12 +0000

Edibles wouldn't have enough sugar to singularly cause diabetes.

New comment by yosame in "ADHD drug treatment and risk of negative events and outcomes"

yosame — Sat, 16 Aug 2025 00:33:16 +0000

There was a study where they tested the effects of ADHD meds on test performance and perceived performance. It found that stimulants increased perceived performance for everyone, but actual test scores were only improved for people with ADHD.

This is a good overview of the literature: https://www.frontiersin.org/journals/neuroscience/articles/1...

New comment by yosame in "Sleep is essential – researchers are trying to work out why"

yosame — Fri, 11 Apr 2025 13:19:07 +0000

In countries with subsidised health care there's still an incentive to solve these problems, since the solution will lower healthcare costs.

New comment by yosame in "X, Facebook, Instagram, and YouTube sign EU code to tackle hate speech"

yosame — Tue, 21 Jan 2025 10:15:59 +0000

How is footage that musk himself reposted misinformation?

New comment by yosame in "TikTok says it is restoring service for U.S. users"

yosame — Mon, 20 Jan 2025 12:08:05 +0000

I don't think it's any worse than any other form of media (like reading comments on hacker news instead of reading the article)

New comment by yosame in "Ending our third party fact-checking program and moving to Community Notes model"

yosame — Tue, 07 Jan 2025 23:37:04 +0000

Calling trans men "distraught girls" is just pure transphobia.

New comment by yosame in "Australia: Kids under 16 to be banned from social media after Senate passes laws"

yosame — Sat, 30 Nov 2024 06:10:45 +0000

Proof:

https://www.accc.gov.au/by-industry/digital-platforms-and-se...

It's called the news media bargaining code. Technically speaking, the law isn't enforced since Google/Meta chose to voluntarily pay the link tax, rather than be put on the list that would force them to pay. But, at the end of the day it's the same effect.

New comment by yosame in "Australia: Kids under 16 to be banned from social media after Senate passes laws"

yosame — Sat, 30 Nov 2024 05:54:53 +0000

Because they won't be forced to provide identification directly, they'll be forced to provide an age verification token that's linked to government identification. It's the same end result (a way to link your identity to the sites you use), but with extra steps.

And honestly with the government's track record when it comes to privacy and technology, I don't think they deserve the benefit of the doubt.

New comment by yosame in "Developing a cancer drug without Big Pharma: this hospital shows it can be done"

yosame — Sat, 30 Nov 2024 02:17:47 +0000

Well to be fair, big pharma doesn't release preclinical results the same way that academia does. There might be no published work to support the hypothesis, but that doesn't mean they haven't done preclinical work.

New comment by yosame in "The weak science behind psychedelics"

yosame — Sun, 27 Oct 2024 02:20:47 +0000

They absolutely can be patented, look at what happened with esketamine. If these molecules work, pharma will just change them slightly (or reformulate) and sell them at a premium.

New comment by yosame in "Z-Library admins "escape house arrest" after judge approves U.S. extradition"

yosame — Mon, 08 Jul 2024 23:00:16 +0000

I don't think crypto wpuld help in this instance, they'd still have to turn it into fiat to do anything with it.

New comment by yosame in "Vigorous Exercise, Cognitive Decline, and High Blood Pressure"

yosame — Wed, 26 Jun 2024 12:36:31 +0000

I'd argue that it's harder to quit compulsive eating than it is to quit compulsive smoking. You can't go cold turkey on food

New comment by yosame in "Psychedelics are challenging the standard of randomized controlled trials"

yosame — Tue, 04 Jun 2024 07:44:30 +0000

Because they still have a developed (if atrophying) visual cortex to generate the visual hallucinations.